Effect of Human Placental Extract on Health Status in Elderly Koreans

Table 3

Change of risk factors of cardiovascular disease in the two study groups.

	Placebo			HPE			P value (Placebo versus HPE)^‡
	Baseline (𝑛=18)	End (𝑛=17)	Difference^†	Baseline (𝑛=22)	End (𝑁=22)	Difference^†
SBP (mmHg)	132.1 ± 11.9^a	129.6 ± 15.1^c	−0.8 ± 16.4^c	132.8 ± 11.24^d	135.5 ± 13.0^b	2.5 ± 11.3^bd	0.860
DBP (mmHg)	81.5 ± 6.1^a	85.0 ± 8.3^c	4.6 ± 10.5^c	83.9±8.9	83.7 ± 9.0^b	0.5 ± 9.6^b	0.250
FPG (mg/dL)	101.8±11.5	100.1 ± 9.7^d	−1.9 ± 6.8^d	102.5 ± 13.32^e	97.0 ± 11.6^f	−1.0 ± 9.3^f	0.842
Insulin (μIU/mL)	6.4±3.7	5.0±3.7	−1.5±3.8	7.9 ± 3.8^d	7.3 ± 5.0^d	−1.2±4.3	0.640
HOMA-IR	1.62±1.02	1.13±0.77	−0.51±0.93	1.95 ± 1.06^d	1.90 ± 1.42^d	−0.05 ± 0.85^d	0.094
QUICKI	0.37±0.04	0.40±0.06	0.03±0.04	0.35±0.05	0.36±0.05	0.01±0.03	0.062
Total cholesterol (mg/dL)	186.0±34.0	184.8±35.0	−2.1±22.5	197.7±36.9	195.4±46.7	−2.3±25.0	0.843
Triglyceride (mg/dL)	149.9±64.3	144.6±47.8	−8.4±55.1	167.1±83.3	143.3 ± 57.9^d	−5.0±61.2	0.966
HDL cholesterol (mg/dL)	51.8±10.5	50.8±5.9	−0.8±7.4	49.9±9.0	50.2±7.5	1.7 ± 7.1^d	0.480
hs-CRP (mg/dL)	0.12 ± 0.11^d	0.08 ± 0.05^e	−0.36 ± 1.35^e	0.15 ± 0.15^d	0.17 ± 0.19^d	0.002±0.105 ^g	0.731

Mean ± SD, ^a1 data missing, ^b3 data missing, ^c5 data missing, ^d1 data exclusion d/t extreme value within group, ^e2 data exclusion d/t extreme values within group, ^f3 data exclusion d/t extreme values within group, ^g4 data exclusion d/t extreme values within group, ^†change from baseline (after-baseline), ^‡P values are for the comparison between groups (change from baseline), HPE: human placental extract, SBP: systolic blood pressure, DBP: diastolic blood pressure, FPG: fasting plasma glucose, HOMA-IR: homeostasis model assessment of insulin resistance, QUICKI: the quantitative insulin sensitivity check index, HDL: high-density lipoprotein, and hs-CRP: high-sensitivity C reactive protein.