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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 735191, 8 pages
Research Article

A Six-Month Supplementation of Mulberry, Korean Red Ginseng, and Banaba Decreases Biomarkers of Systemic Low-Grade Inflammation in Subjects with Impaired Glucose Tolerance and Type 2 Diabetes

1Department of Food and Nutrition, Sookmyung Women’s University, Yongsan-gu, Seoul 140-742, Republic of Korea
2Department of Endocrinology and Metabolism, Seoul St. Mary’s Hospital The Catholic University of Korea, Seocho-gu, Seoul 137-701, Republic of Korea
3Department of Preventive Medicine, Seoul St. Mary’s Hospital The Catholic University of Korea, Seocho-gu, Seoul 137-701, Republic of Korea
4Korea Ginseng Manufacturing Plant, National Agricultural Cooperative Federation, Chung-buk 368-811, Republic of Korea
5Clinical Nutrition & Risk Factor Modification Center, St. Michael's Hospital and, Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada M5C 1N8

Received 5 October 2011; Revised 19 December 2011; Accepted 20 December 2011

Academic Editor: Cheorl-Ho Kim

Copyright © 2012 H.-J. Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We sought the long-term efficacy of traditionally used antidiabetic herbs in controlling blood glucose homeostasis and low-grade inflammation. Ninety-four subjects with either impaired glucose tolerance or mild T2D were randomized either to treatment arm or placebo arm and received 1 : 1 : 1 mixture of ginseng roots, mulberry leaf water extract, and banaba leaf water extract (6 g/d) for 24 weeks. Oral 75 g glucose tolerance test was performed to measure glucose and insulin responses. Blood biomarkers of low-grade inflammation were also determined. Results found no significant difference in glucose homeostasis control measure changes. However, plasma intracellular adhesion molecule-1 (ICAM-1) concentration was decreased showing a significant between-treatment changes ( ). The concentrations of vascular cell adhesion molecule-1 (VCAM-1) ( ) and ICAM-1 ( ) were decreased in the treatment group at week 24, and the oxidized low-density lipoprotein (ox-LDL) concentration was reduced at week 24 compared to the baseline value in the treatment group ( ). These results indicate a long-term supplementation of ginseng, mulberry leaf, and banaba leaf suppresses inflammatory responses in T2D.