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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 735481, 11 pages
Research Article

The Yang-Tonifying Herbal Medicine Cynomorium songaricum Extends Lifespan and Delays Aging in Drosophila

1Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan
2Department of Biotechnology, Asia University, Taichung 41354, Taiwan
3Graduate Institute of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
4Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan
5Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan

Received 11 April 2012; Accepted 17 June 2012

Academic Editor: I-Min Liu

Copyright © 2012 Hsin-Ping Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aging is highly correlated with the progressive loss of physiological function, including cognitive behavior and reproductive capacity, as well as an increased susceptibility to diseases; therefore, slowing age-related degeneration could greatly contribute to human health. Cynomorium songaricum Rupr. (CS) is traditionally used to improve sexual function and treat kidney dysfunction in traditional Chinese medicine, although little is known about whether CS has effects on longevity. Here, we show that CS supplementation in the diet extends both the mean and maximum lifespan of adult female flies. The increase in lifespan with CS was correlated with higher resistance to oxidative stress and starvation and lower lipid hydroperoxides (LPO) levels. Additionally, the lifespan extension was accompanied by beneficial effects, such as improved mating readiness, increased fecundity, and suppression of age-related learning impairment in aged flies. These findings demonstrate the important antiaging effects of CS and indicate the potential applicability of dietary intervention with CS to enhance health and prevent multiple age-related diseases.