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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 747969, 6 pages
http://dx.doi.org/10.1155/2012/747969
Research Article

Evaluation of the Antimicrobial Activity of the Decoction of Tropidurus hispidus (Spix, 1825) and Tropidurus semitaeniatus (Spix, 1825) Used by the Traditional Medicine

1Laboratory of Zoology, Regional University of Cariri-URCA, Pimenta 63105-000, Crato, CE, Brazil
2Laboratory of Microbiology and Molecular Biology, Regional University of Cariri-URCA, Pimenta 63105-000, Crato, CE, Brazil
3Laboratory of Natural Products Research, Regional University of Cariri-URCA, Pimenta 63105-000, Crato, CE, Brazil
4Laboratory of Phamacology and Medicinal Chemistry, Regional University of Cariri-URCA, Pimenta 63105-000, Crato, CE, Brazil
5Department of Biology, Paraiba State University-UEPB, Joăo Pessoa 58429-500, PB, Brazil

Received 1 April 2011; Accepted 4 May 2011

Academic Editor: Ana H. Ladio

Copyright © 2012 Israel J. M. Santos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tropidurus hispidus and Tropidurus semitaeniatus are two lizard species utilized in traditional medicine in Northeast Brazil. Their medicinal use includes diseases related with bacterial infections such as tonsillitis and pharyngitis. They are used in the form of teas (decoctions) for the treatment of illnesses. In this work, we evaluated the antimicrobial activity of the decoctions of T. hispidus (DTH) and T. semitaeniatus (DTS) against bacterial strains, namely, standard and multiresistant Escherichia coli, Staphylococus aureus, and Pseudomonas aureuginosa, alone and in combination with aminoglycoside antibiotics. The decoctions were prepared using the whole body of the dried lizards, and the filtrate was frozen and lyophilized. When tested alone, the samples did not demonstrate any substantial inhibition of bacterial growth. However, in combination with antibiotics as aminoglycosides, decoctions reduced the minimal inhibitory concentration (MIC) of the assayed antibiotics against multiresistant strains of S. aureus and P. aureuginosa. Chemical prospecting tests revealed the presence of alkaloids in DTS. This is the first study evaluating the medicinal efficacy of T. hispidus and T. semitaeniatus and contributes to the list of new sources of medicines from natural products of animal origin.