Flavonoid Myricetin Modulates
Receptor Activity through Activation of Channels and CaMK-II Pathway
Myricetin-induced intracellular Ca2+ increase in the primary culture of rat hypothalamus neurons and the effects of Ca2+ channel blockers. (a) Images of rat hypothalamus neurons before and after 50 μM myricetin perfusion, showing increased Ca2+ dye intensity; (b) effect of Ca2+ channel blockers on myricetin induced intracellular Ca2+ increase (***, versus 50 μM myricetin, one-way ANOVA). Mibefradil is T-type Ca2+ channel blocker; nifedipine is L-type Ca2+ channel blocker. Numbers on the top of each bar represent the numbers of cells examined.
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