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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 769830, 10 pages
http://dx.doi.org/10.1155/2012/769830
Research Article

Herbal Formula, PM014, Attenuates Lung Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease

1Department of Oriental Physiology, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea
2Division of Pharmacognosy, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea
3Department of Life and Nanopharmaceutical Sciences, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea
4Division of Allergy and Respiratory System, Department of Oriental Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea

Received 5 October 2011; Accepted 28 February 2012

Academic Editor: Xiu-Min Li

Copyright © 2012 Hyojung Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chronic obstructive pulmonary disease (COPD), which is characterized by airway obstruction, leads to, as the two major forms of COPD, chronic bronchitis and emphysema. This study was conducted to evaluate the effects of herbal formula, PM014, in a murine model of COPD. Balb/c mice were treated once with each herb extract in PM014 or PM014 mixture via an oral injection. Lipopolysaccharide (LPS) or elastase/LPS were administrated to the mice to induce a disease that resembles COPD. PM014 treatment significantly attenuated the increased accumulation of immune cells in bronchoalveolar lavage fluid (BALF) compared to control mice. In addition, the TNF-α and IL-6 levels in BALF were decreased in the PM014 mice. Furthermore, histological analysis demonstrated that PM014 attenuated the hazardous effects of lung inflammation. These data suggest that PM014 exerts beneficial effects against forms of COPD such as lung inflammation.