Activation of Spinal 𝜶2-Adrenoceptors Using Diluted Bee Venom Stimulation Reduces Cold Allodynia in Neuropathic Pain Rats

Figure 1

Effect of single DBV treatment on cold allodynia. A graph illustrating the effect of single treatment with diluted bee venom (DBV) on cold allodynia in neuropathic rats. All the CCI-subjected animal groups (Saline, DBV (2.5 mg), DBV (0.25 mg)) significantly increased paw withdrawal frequency (PWF, %) to innocuous cold stimulus compared with that of the sham surgery animals (Sham, ***𝑃<0.001). Moreover, the high-dose DBV treatment group (DBV (2.5 mg)) significantly suppressed the CCI-induced PWF from 45 minutes to 90 minutes after DBV treatment compared with the saline-treated group (Saline, ^##𝑃<0.01 and ^### 𝑃<0.001).