Activation of Spinal 2-Adrenoceptors Using Diluted Bee Venom Stimulation Reduces Cold Allodynia in Neuropathic Pain Rats
Figure 3
Effect of combined DBV and clonidine treatment on neuropathic pain-induced cold allodynia. A graph demonstrating the analgesic effects of intrathecal clonidine alone or in combination with injection of subcutaneous diluted bee venom (DBV) on CCI-induced cold allodynia. Rats were injected intrathecally with saline (Sal) or clonidine (CLO) 5 minutes after subcutaneous injection of saline or DBV. The intrathecal clonidine-injected rats (Sal + CLO (5 nmol) and Sal + CLO (15 nmol)) dose-dependently suppressed CCI-induced cold allodynic behavior compared with the saline-treated group (Sal + Sal, * and ***) while the low-dose clonidine group (Sal + CLO (1 nmol)) and DBV injection without clonidine treatment (DBV (0.25 mg) + Sal) had no effect. The combined group of DBV acupuncture and low-dose clonidine (DBV (0.25 mg) + CLO (1 nmol)) significantly reversed CCI-injured cold allodynia compared with the control group (Sal + Sal, * and ***).
