Activation of Spinal 2-Adrenoceptors Using Diluted Bee Venom Stimulation Reduces Cold Allodynia in Neuropathic Pain Rats
Figure 5
Effect of intrathecal α2-adrenoceptor antagonist injection on the repetitive DBV-induced antinociception. The effects of intrathecal α2-adrenoceptor antagonists on repetitive diluted-bee-venom-(DBV-) induced decrease of cold allodynia in CCI animals. Saline and idazoxan were intrathecally injected after repetitive saline and DBV treatment for 2 consecutive weeks. In the repetitive saline injection group, intrathecal idazoxan injection (R-Sal: Idazoxan) did not change the cold allodynic behavior compared with the saline-injected animals (R-Sal: Saline), whereas intrathecal idazoxan injection in the repetitive DBV group (R-DBV (0.25 mg): Idazoxan) significantly reversed the reduced response to cold stimulus compared with the saline-treated rats (R-DBV (0.25 mg): Saline, *).
