Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract of Jasminum sambac against HCl/Ethanol-Induced Gastric Mucosal Injury in Rats
Figure 4
Histological study of HCl/ethanol-induced gastric mucosal damage in rats. (a) Rats pretreated with 5 mL/kg of CMC (Normal control group). No injuries to the gastric mucosa are seen. (b) Rats pretreated with 5 mL/kg of CMC (ulcer control group). There is severe disruption to the surface epithelium and necrotic lesions penetrating deeply into mucosa and extensive edema of submucosa layer and leucocytes infiltration is present. (c) Rats pretreated with omeprazole (20 mg/kg). Mild disruption of the surface epithelium mucosa is seen. There is edema and leucocytes infiltration of the submucosal layer. (d) Rat pretreated with J. sambac extract (62.50 mg/kg). Moderate disruption of surface epithelium is present. There is submucosal edema and leucocytes infiltration. (e) Rats pretreated with J. sambac extract (125 mg/kg). There is mild disruption to the surface epithelium. There is edema with leucocytes infiltration of the submucosal layer. (f). Rats pretreated with J. sambac extract (250 mg/kg). There is mild disruption to the surface epithelium. There is no edema or leucocytes infiltration of the submucosal layer. (g) Rats pretreated with J. sambac extract (500 mg/kg). There is no disruption to the surface epitheliumand no edema or leucocytes infiltration of the submucosal layer (H&E stain 10×).
