Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 2

Review Article

The Tibetan Uterotonic Zhi Byed 11: Mechanisms of Action, Efficacy, and Historical Use for Postpartum Hemorrhage

Table 2

Potential mechanisms of action of Zhi Byed 11.

Tibetan nameaMechanism of action

lcum rtsaAnthranoids: laxative due to direct colon irritation, purgative potentially due to abnormal expression of aquaporins [27].
Emodins: dose-dependant smooth muscle contraction [28] due to increased concentration of calcium in smooth muscle and the activation of calcium chloride channels via enhancement of membrane Gi/Go protein signal transducer pathway [29]. CaCl2 can reverse effects. Heightens effects of Acetylcholine [28].
Sennosides: animal studies demonstrate intestinal peristalsis due to depolarization of cell membranes, quickened burst slow wave potential, and increased frequency of spike potentials [30].

ma nuHighly potent tracheal and ileal smooth muscle relaxant in animal studies [30].

sga skyaDecreases nausea and vomiting [31] and prokinetic activity in digestive system of animal models due to effects on muscarinic M3 receptors of stomach fundus [32].

star buAnthranoids: Laxative due to direct colon irritation [19].

aStudies on sbrul sha, ol mo’se, rgya tsha, a ru, bul tog, cong zhi, and sdig srin are not found.

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