Research Article

The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway

Table 2

The effects of the fractions of F. macrophylla on the levels of extracellular and intracellular Aβ1-40. APP-transfected N2a cells were treated with the fractions of F. macrophylla at the STC for 20 h. The level of extracellular and intracellular Aβ1-40 was determined by ELISA. Results are means ± SD from three independent experiments. Significant differences between control and fractions-treated cells are indicated by * , ** , and *** .

Fractions STC (μg/mL) Aβ1-40 (% of control)
ExtracellularIntracellular

EtOH10 ***
H2O100 *** ***
H25M1 * nda
H50M1 nd
H75M50 *** ***
H100M1 ** nd
BuOH1 *** nd
B25M1 * nd
B50M10 ***
B75M50 *** ***
B100M50 ** nd
EA1 nd
EA-110 ** nd
EA-41 nd
EA-3510 * nd
EA-521 * nd
EA-551 ** nd
EA-741 **
EA-791 nd
EA-851 nd
EA-941 nd
EA-1031 * nd
EA-1211 ** nd
EA-1651 * nd

and, not determined.