Bioassay-Guided Isolation of Neuroprotective Compounds from Uncaria rhynchophylla against Beta-Amyloid-Induced Neurotoxicity

Figure 5

Effect of rhynchophylline and isorhynchophylline on tau protein hyperphosphorylation in A𝛽₂₅₋₃₅-treated PC12 cells. The tau protein hyperphosphorylation was assessed by measuring the phosphorylated tau protein (at Thr 205, Ser 396, and Ser 404 sites) and total tau. Values given are the mean ± SEM (𝑛=3). ^#𝑃<0.01 compared with the control group; *𝑃<0.05 and **𝑃<0.01 compared with the A𝛽₂₅₋₃₅-treated control.

(a)

(b)

(c)

(d)