The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker
Figure 3
The effects of retigabine, flupirtine, and lamotrigine on the duration of isometric twitches induced by 9-AC (0.1 mM). The representative traces of muscle twitches showed the effects of retigabine (0.03 mM, (a)), flupirtine (0.03 mM, (b)), and lamotrigine (0.03 mM, (c)) on the prolonged duration of muscle twitches induced by 9-AC. Retigabine and flupirtine shortened the duration of muscle twitches in the presence of 9-AC. Linopirdine (0.05 mM), a KCNQ blocker, antagonises the effects of retigabine and flupirtine on the duration of muscle twitches. *a high-resolution time scale: 200 msec.
