The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker

<table>The effects of retigabine, flupirtine, and lamotrigine on the maximum rise slope of action potentials. The effects of retigabine (0.03 mM), flupirtine (0.03 mM), and lamotrigine (0.03 mM) on the maximum rise slope of action potentials are shown in (a, b, and c), respectively. *<svg height="11.375" id="M64" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg> as compared with before the chemical treatment.</table>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker 