Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 803239, 8 pages
http://dx.doi.org/10.1155/2012/803239
Research Article

Safety and Efficacy of Tien-Hsien Liquid Practical in Patients with Refractory Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase IIa Trial

1Department of General Surgery, National Taiwan University Hospital, Taipi, Taiwan
2Department of Family Medicine, National Taiwan University Hospital, Taipi, Taiwan
3Gerent Biotech Co., Ltd., Taichung, Taiwan
4Department of Surgery, Cheng Ching General Hospital, Taichung, Taiwan

Received 15 December 2011; Accepted 18 January 2012

Academic Editor: Wolfgang Weidenhammer

Copyright © 2012 Wen-Hung Kuo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar
  2. F. Cardoso and M. Castiglione, “Locally recurrent or metastatic breast cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 20, supplement 4, pp. iv15–iv18, 2009. View at Publisher · View at Google Scholar
  3. Taiwan Cancer Registry, http://tcr.cph.ntu.edu.tw/uploadimages/Top%2010%20cancer%20in%20Taiwan%202008.pdf.
  4. H. Roché and L. T. Vahdat, “Treatment of metastatic breast cancer: second line and beyond,” Annals of Oncology, vol. 22, no. 5, pp. 1000–1010, 2011. View at Publisher · View at Google Scholar
  5. Y. Fernández, J. Cueva, A. G. Palomo et al., “Novel therapeutic approaches to the treatment of metastatic breast cancer,” Cancer Treatment Reviews, vol. 36, no. 1, pp. 33–42, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. J. S. Chia, J. L. Du, W. B. Hsu, A. Sun, C. B. Chiang, and W. B. Wang, “Inhibition of metastasis, angiogenesis, and tumor growth by chinese herbal cocktail Tien-Hsien Liquid,” BMC Cancer, vol. 10, p. 175, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. C.-J. Yao, C.-M. Yang, S.-E. Chuang et al., “Targeting PML-RARα and oncogenic signaling pathways by chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 984154, 11 pages, 2011. View at Publisher · View at Google Scholar
  8. K. K. Chan, T. J. Yao, B. Jones et al., “The use of chinese herbal medicine to improve quality of life in women undergoing chemotherapy for ovarian cancer: a double-blind placebo-controlled randomized trial with immunological monitoring,” Annals of Oncology, vol. 22, no. 10, pp. 2241–2249, 2011. View at Publisher · View at Google Scholar
  9. A. Sun, J. S. Chia, C. P. Chiang et al., “The chinese herbal medicine Tien-Hsien liquid inhibits cell growth and induces apoptosis in a wide variety of human cancer cells,” Journal of Alternative and Complementary Medicine, vol. 11, no. 2, pp. 245–256, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Boon, M. Stewart, M. A. Kennard et al., “Use of complementary/alternative medicine by breast cancer survivors in Ontario: prevalence and perceptions,” Journal of Clinical Oncology, vol. 18, no. 13, pp. 2515–2521, 2000. View at Google Scholar · View at Scopus
  11. M. A. Richardson, T. Sanders, J. L. Palmer, A. Greisinger, and S. E. Singletary, “Complementary/alternative medicine use in a comprehensive cancer center and the implications for oncology,” Journal of Clinical Oncology, vol. 18, no. 13, pp. 2505–2514, 2000. View at Google Scholar · View at Scopus
  12. J. Shen, R. Andersen, P. S. Albert et al., “Use of complementary/alternative therapies by women with advanced-stage breast cancer,” BMC Complementary and Alternative Medicine, vol. 2, no. 1, article no. 8, p. 8, 2002. View at Google Scholar · View at Scopus
  13. B. Gerber, C. Scholz, T. Reimer, V. Briese, and W. Janni, “Complementary and alternative therapeutic approaches in patients with early breast cancer: a systematic review,” Breast Cancer Research and Treatment, vol. 95, no. 3, pp. 199–209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. A. Sun, J. S. Chia, W. B. Wang, and C. P. Chiang, “Immunomodulating effects of "Tien-Hsien liquid" on peripheral blood mononuclear cells and T-lymphocytes from patients with recurrent aphthous ulcerations,” American Journal of Chinese Medicine, vol. 32, no. 2, pp. 221–234, 2004. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Sun, J. S. Chia, W. B. Wang, and C. P. Chiang, “‘Tien-hsien liquid’ can modulate antigen-stimulated cytokine production by T-cells isolated from patients with recurrent aphthous ulcerations,” American Journal of Chinese Medicine, vol. 33, no. 4, pp. 559–571, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Svensson, T. Hatschek, H. Johansson, Z. Einbeigi, and Y. Brandberg, “Health-related quality of life as prognostic factor for response, progression-free survival, and survival in women with metastatic breast cancer,” Medical Oncology. In press. View at Publisher · View at Google Scholar
  17. L. C. Chen, B. R. Wang, Y. C. Chou, and J. H. Tien, “Drug utilization pattern of chinese herbal medicines in a general hospital in Taiwan,” Pharmacoepidemiology and Drug Safety, vol. 14, no. 9, pp. 651–657, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Ernst, “Herbal medicines put into context,” British Medical Journal, vol. 327, no. 7420, pp. 881–882, 2003. View at Google Scholar · View at Scopus
  19. T. S. Mok, W. Yeo, P. J. Johnson et al., “A double-blind placebo-controlled randomized study of chinese herbal medicine as complementary therapy for reduction of chemotherapy-induced toxicity,” Annals of Oncology, vol. 18, no. 4, pp. 768–774, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Q. Li, L. C. He, H. Y. Dong, and J. Q. Jin, “Screening for the anti-inflammatory activity of fractions and compounds from atractylodes macrocephala koidz,” Journal of Ethnopharmacology, vol. 114, no. 2, pp. 212–217, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. [No authors listed], “Astragalus membranaceus. Monograph,” Alternative Medicine Review—A Journal of Clinical Therapeutics, vol. 8, no. 1, pp. 72–77, 2003. View at Google Scholar
  22. Y.-H. Kim, S.-J. Choo, I.-J. Ryoo, J.-S. Ahn, and I.-D. Yoo, “Eudesmanolides from taraxacum mongolicum and their inhibitory effects on the production of nitric oxide,” Archives of Pharmacal Research, vol. 34, no. 1, pp. 37–41, 2011. View at Publisher · View at Google Scholar
  23. J.-L. Ríos, “Chemical constituents and pharmacological properties of poria cocos,” Planta Medica, vol. 77, no. 7, pp. 681–691, 2011. View at Publisher · View at Google Scholar
  24. X. Ran, L. Ma, C. Peng, H. Zhang, and L.-P. Qin, “Ligusticum chuanxiong Hort: a review of chemistry and pharmacology,” Pharmaceutical Biology, vol. 49, no. 11, pp. 1180–1189, 2011. View at Publisher · View at Google Scholar
  25. D. Gao, Q. Li, Y. Li et al., “Antidiabetic and antioxidant effects of oleanolic acid from Ligustrum lucidum ait in alloxan-induced diabetic rats,” Phytotherapy Research, vol. 23, no. 9, pp. 1257–1262, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. X. Sun, “Immunological adjuvant effect of awater-soluble polysaccharide, CPP, from the roots of codonopsis pilosula on the immune responses to ovalbumin in mice,” Chemistry and Biodiversity, vol. 6, no. 6, pp. 890–896, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. B.-S. Ko, J. S. Jang, S. M. Hong et al., “Changes in components, glycyrrhizin and glycyrrhetinic acid, in raw glycyrrhiza uralensis fisch, modify insulin sensitizing and insulinotropic actions,” Bioscience, Biotechnology and Biochemistry, vol. 71, no. 6, pp. 1452–1461, 2007. View at Publisher · View at Google Scholar
  28. J. Lin, L. Wei, W. Xu, Z. Hong, X. Liu, and J. Peng, “Effect of hedyotis diffusa willd extract on tumor angiogenesis,” Molecular Medicine Reports, vol. 4, no. 6, pp. 1283–1288, 2011. View at Publisher · View at Google Scholar
  29. C. K. Wong, K. N. Leung, K. P. Fung, and Y. M. Choy, “The immunostimulating activities of anti-tumor polysaccharides from pseudostellaria heterophylla,” Immunopharmacology, vol. 28, no. 1, pp. 47–54, 1994. View at Publisher · View at Google Scholar · View at Scopus
  30. W. He, L. Y. Chan, G. Zeng, N. L. Daly, D. J. Craik, and N. Tan, “Isolation and characterization of cytotoxic cyclotides from viola philippica,” Peptides, vol. 32, no. 8, pp. 1719–1723, 2011. View at Publisher · View at Google Scholar