Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling

Scheme 1

^aReaction conditions were as follows: (i) diethyl succinate, EtONa, EtOH, 70°C; (ii) 10% Pd/C, H₂, MeOH, rt; (iii) KOH, CaCl₂, EtOH, 0°C; (iv) NaBH₄, rt; (v) 3 M HCl, rt; (vi) LDA, 3,4,5-trimethoxybenzaldehyde, THF, −78°C, (vii) MsCl, TEA, CH₂Cl₂, 0°C; (viii) DBU, CH₃CN, rt; (ix) Ac₂O, TEA, DMAP, CH₂Cl₂, rt; (x) DBU, PhCH₃, 80°C.