Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch Signaling

Table 1

Growth inhibition of K8, E-K8, or Z-K8 against human tumor cell lines.

Cell line	Origin	IC50 (𝜇M)
		K8	E-K8	Z-K8
AGS	Gastric carcinoma	ND	ND	2.5
J5	Hepatocarcinoma	21.5	ND	2.5
LNCaP	Androgen-dependent,; prostate adenocarcinoma	4.3	>20	1
PC3	Androgen-independent, prostate adenocarcinoma	>20	>20	4.5
A549	Lung adenocarcinoma	18.5	>20	5
H460	Lung adenocarcinoma	20.0	>20	10.0
H1299	Lung adenocarcinoma	20.5	>20	12.5
A549-T12	Lung adenocarcinoma	10.0	>20	4.5
OEC-M1	Oral squamous cell carcinoma	ND	>1	1

IC₅₀: drug concentration that inhibits cell division by 50% after 48 h.
ND: not determined, or concentration >100 𝜇M.