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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 818261, 13 pages
Research Article

Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo

1Department of Dermatology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
2Department of Child Care, College of Humanities and Social Sciences, Southern Taiwan University, Tainan 71005, Taiwan
3Institute of Biomedical Sciences, College of Life Science, National Chung Hsing University, Taichung 40227, Taiwan
4Agricultural Research Institute, Council of Agriculture Executive, Yuan 10014, Taiwan
5Department of Internal Medicine, Division of Chest Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
6Department of Medical Education and Research, Taichung-Veterans General Hospital, Taichung 40705, Taiwan
7Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan

Received 18 February 2011; Accepted 18 April 2011

Academic Editor: José L. Ríos

Copyright © 2012 Chieh-Shan Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Effects of terpinen-4-ol on the expression of cell cycle-related proteins in A549 and CL1-0 cells. Cells were treated with indicated concentrations of terpinen-4-ol for 24 hr. Total cell lysates prepared were subjected to SDS-PAGE and immunoblotted with antibodies to detect cyclin B1, phospho-cdc2 (Tyr15), Cdc25, p27 and p21 protein expressions. Data correspond to a representative of three independent experiments with similar results.

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