Inhibition of Activity of GABA Transporter GAT1 by -Opioid Receptor
Dependence of GAT1-mediated rate of [3H]GABA uptake on different amounts of coinjected cRNA. For cRNA of OR (filled squares) or r2 pumps (filled circles), the amount of injected cRNA for GAT1 was 40 ng. Data were normalized for each batch of oocytes to the respective value obtained from oocytes not coinjected with cRNA for OR or r2 and are presented as means SEM from 2 to 3 batches of oocytes (with 8–10 oocytes per batch). The dependence of rate of GABA uptake on OR-cRNA was fitted by (1).