Inhibition of Activity of GABA Transporter GAT1 by -Opioid Receptor
Effects of opioid receptor coexpression on GAT1-mediated current. (a) Current traces in response to rectangular voltage pulses before, during, and after application of 100 M GABA to oocytes with expressed GAT1. Effects on the voltage dependence of steady-state GAT1-mediated currents in oocytes coexpressed with OR or OR (10 ng cRNA coinjected) (b) and of their activation by 100 nM DPDPE or DAMGO, respectively (c). Data in (b) and (c) represent averages SEM of at least 6 oocytes.