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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 820415, 13 pages
Research Article

Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice

1Division of Palliative Care and Department of Internal Medicine, Tokai Central Hospital, 4-6-2 Sohara-Higashijima-cho, Kakamigahara 504-8601, Japan
2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch-cho, Sasebo 859-3298, Japan
3Department of Pathology, Murakami Memorial Hospital, Asahi University, 3-23 Hashimoto-cho, Gifu 500-8523, Japan
4Department of Pharmacy, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki 503-8502, Japan
5Division of Cytopathology, The Tokai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami-Uzura, Gifu 500-8285, Japan
6Department of Tumor Pathology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan

Received 5 November 2012; Revised 4 December 2012; Accepted 6 December 2012

Academic Editor: Chong-Zhi Wang

Copyright © 2012 Kunihiro Kawabata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [9 citations]

The following is the list of published articles that have cited the current article.

  • Jae Ho Choi, Sun Woo Jin, Bong Hwan Park, Hyung Gyun Kim, Tilak Khanal, Hwa Jeong Han, Yong Pil Hwang, Jun Min Choi, Young Chul Chung, Sang Kyu Hwang, Tae Cheon Jeong, and Hye Gwang Jeong, “Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells,” Food and Chemical Toxicology, vol. 56, pp. 195–203, 2013. View at Publisher · View at Google Scholar
  • Adrian L. Lopresti, and Peter D. Drummond, “ Saffron ( Crocus sativus ) for depression: a systematic review of clinical studies and examination of underlying antidepressant mechanisms of action ,” Human Psychopharmacology: Clinical and Experimental, 2014. View at Publisher · View at Google Scholar
  • Wenkai Ren, Jie Yin, Miaomiao Wu, Gang Liu, Guan Yang, Yan Xion, Dingding Su, Li Wu, Tiejun Li, Shuai Chen, Jielin Duan, Yulong Yin, and Guoyao Wu, “Serum Amino Acids Profile and the Beneficial Effects of L-Arginine or L-Glutamine Supplementation in Dextran Sulfate Sodium Colitis,” Plos One, vol. 9, no. 2, 2014. View at Publisher · View at Google Scholar
  • Masahito Shimizu, Takahiro Kochi, Yohei Shirakami, Salvatore Genovese, Francesco Epifano, Serena Fiorito, Takayuki Mori, Takuji Tanaka, and Hisataka Moriwaki, “ A newly synthesized compound, 4′-geranyloxyferulic acid- N (omega)-nitro- l -arginine methyl ester suppresses inflammation-associated colorectal carcinogenesis in male mice ,” International Journal of Cancer, vol. 135, no. 4, pp. 774–784, 2014. View at Publisher · View at Google Scholar
  • Kai Wang, Lei Zhang, Wei Rao, Ning Su, Hao Hui, Li Wang, Cheng Peng, Yue Tu, Sai Zhang, and Zhou Fei, “Neuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway,” Neuroscience Letters, vol. 591, pp. 53–58, 2015. View at Publisher · View at Google Scholar
  • Bettina Faehnrich, Brigitte Lukas, Elke Humer, and Qendrim Zebeli, “Phytogenic pigments in animal nutrition: potentials and risks,” Journal of the Science of Food and Agriculture, 2015. View at Publisher · View at Google Scholar
  • Shohda A. El-Maraghy, Sherine M. Rizk, and Nancy N. Shahin, “Gastroprotective effect of crocin in ethanol-induced gastric injury in rats,” Chemico-Biological Interactions, 2015. View at Publisher · View at Google Scholar
  • Mohammad Hossein Boskabady, and Tahereh Farkhondeh, “ Antiinflammatory, Antioxidant, and Immunomodulatory Effects of Crocus sativus L. and its Main Constituents ,” Phytotherapy Research, 2016. View at Publisher · View at Google Scholar
  • Nehal M. Elsherbiny, Mohamed F. Salama, Eman Said, Mohamed El-Sherbiny, and Mohammed M.H. Al-Gayyar, “Crocin protects against Doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways,” Chemico-Biological Interactions, 2016. View at Publisher · View at Google Scholar