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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 820415, 13 pages
Research Article

Dietary Crocin Inhibits Colitis and Colitis-Associated Colorectal Carcinogenesis in Male ICR Mice

1Division of Palliative Care and Department of Internal Medicine, Tokai Central Hospital, 4-6-2 Sohara-Higashijima-cho, Kakamigahara 504-8601, Japan
2Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Nagasaki International University, 2825-7 Huis Ten Bosch-cho, Sasebo 859-3298, Japan
3Department of Pathology, Murakami Memorial Hospital, Asahi University, 3-23 Hashimoto-cho, Gifu 500-8523, Japan
4Department of Pharmacy, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki 503-8502, Japan
5Division of Cytopathology, The Tokai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami-Uzura, Gifu 500-8285, Japan
6Department of Tumor Pathology, Graduate School of Medicine, Gifu University, Gifu 501-1194, Japan

Received 5 November 2012; Revised 4 December 2012; Accepted 6 December 2012

Academic Editor: Chong-Zhi Wang

Copyright © 2012 Kunihiro Kawabata et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [18 citations]

The following is the list of published articles that have cited the current article.

  • Jae Ho Choi, Sun Woo Jin, Bong Hwan Park, Hyung Gyun Kim, Tilak Khanal, Hwa Jeong Han, Yong Pil Hwang, Jun Min Choi, Young Chul Chung, Sang Kyu Hwang, Tae Cheon Jeong, and Hye Gwang Jeong, “Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells,” Food and Chemical Toxicology, vol. 56, pp. 195–203, 2013. View at Publisher · View at Google Scholar
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  • Kai Wang, Lei Zhang, Wei Rao, Ning Su, Hao Hui, Li Wang, Cheng Peng, Yue Tu, Sai Zhang, and Zhou Fei, “Neuroprotective effects of crocin against traumatic brain injury in mice: Involvement of notch signaling pathway,” Neuroscience Letters, vol. 591, pp. 53–58, 2015. View at Publisher · View at Google Scholar
  • Bettina Faehnrich, Brigitte Lukas, Elke Humer, and Qendrim Zebeli, “Phytogenic pigments in animal nutrition: potentials and risks,” Journal of the Science of Food and Agriculture, 2015. View at Publisher · View at Google Scholar
  • Shohda A. El-Maraghy, Sherine M. Rizk, and Nancy N. Shahin, “Gastroprotective effect of crocin in ethanol-induced gastric injury in rats,” Chemico-Biological Interactions, 2015. View at Publisher · View at Google Scholar
  • Mohammad Hossein Boskabady, and Tahereh Farkhondeh, “ Antiinflammatory, Antioxidant, and Immunomodulatory Effects of Crocus sativus L. and its Main Constituents ,” Phytotherapy Research, 2016. View at Publisher · View at Google Scholar
  • Intidhar Ben Salem, Manel Boussabbeh, Alexandre Prola, Arnaud Guilbert, Hassen Bacha, Christophe Lemaire, and Salwa Abid-Essefi, “Crocin protects human embryonic kidney cells (HEK293) from α- and β-Zearalenol-induced ER stress and apoptosis,” Environmental Science and Pollution Research, 2016. View at Publisher · View at Google Scholar
  • Marzyeh Kamyar, Soghra Mehri, Bibi Marjan Razavi, Faezeh Vahdati Hasani, Amir Foroutanfar, and Hossein Hosseinzadeh, “Crocin prevents haloperidol-induced orofacial dyskinesia: Possible an antioxidant mechanism,” Iranian Journal of Basic Medical Sciences, vol. 19, no. 10, pp. 1070–1079, 2016. View at Publisher · View at Google Scholar
  • Nehal M. Elsherbiny, Mohamed F. Salama, Eman Said, Mohamed El-Sherbiny, and Mohammed M.H. Al-Gayyar, “Crocin protects against Doxorubicin-induced myocardial toxicity in rats through down-regulation of inflammatory and apoptic pathways,” Chemico-Biological Interactions, 2016. View at Publisher · View at Google Scholar
  • Shenglan Yang, Yingying Luo, Kaming Xue, Danfang Deng, Yanran Wu, Rui Zhu, and Yanping Zhou, “NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome,” RSC Advances, vol. 6, no. 69, pp. 64208–64214, 2016. View at Publisher · View at Google Scholar
  • Iliass Lahmass, Touria Lamkami, Cédric Delporte, Sohely Sikdar, Pierre Van Antwerpen, Ennouamane Saalaoui, and Véronique Megalizzi, “The waste of saffron crop, a cheap source of bioactive compounds,” Journal of Functional Foods, vol. 35, pp. 341–351, 2017. View at Publisher · View at Google Scholar
  • Reyhane Hoshyar, and Homa Mollaei, “A comprehensive review on anticancer mechanisms of the main carotenoid of saffron, crocin,” Journal of Pharmacy and Pharmacology, 2017. View at Publisher · View at Google Scholar
  • Yusuke Kanda, Mitsuhiko Osaki, and Futoshi Okada, “Chemopreventive Strategies for Inflammation-Related Carcinogenesis: Current Status and Future Direction,” International Journal of Molecular Sciences, vol. 18, no. 4, pp. 867, 2017. View at Publisher · View at Google Scholar
  • Amr Amin, Yaser Greish, Rkia El-Kharrag, Soleiman Hisaindee, and Sherif M. Karam, “Development of a therapeutic model of precancerous liver using crocin-coated magnetite nanoparticles,” International Journal of Oncology, vol. 50, no. 1, pp. 212–222, 2017. View at Publisher · View at Google Scholar
  • John W. Finley, and Song Gao, “ A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease ,” Journal of Agricultural and Food Chemistry, 2017. View at Publisher · View at Google Scholar
  • Ahmed E. Khodir, Hoda Atef, Eman Said, Hassan A. ElKashef, and Hatem A. Salem, “Implication of Nrf2/HO-1 pathway in the coloprotective effect of coenzyme Q10 against experimentally induced ulcerative colitis,” Inflammopharmacology, vol. 25, no. 1, pp. 119–135, 2017. View at Publisher · View at Google Scholar