Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-𝜶 in High-Fat-Diet-Induced Obese Rats

Table 1

Changes on the body weight (BW), food and water intake, and weight of white adipose tissue (WAT) in HFD-fed rats receiving 12-weeks treatment with VBRB or fenofibrate.

Groups	Initial BW; (g rat^−1)	BW gain; (g rat^−1)	Food intake (g rat^−1 per day)	Water intake (mL rat^−1 per day)	WAT (mg 100 g^−1 BW)
					Epididymal	Perirenal	Mesenteric	Inguinal
RCD-fed
Vehicle-treated	172.5 ± 7.7	17.8 ± 6.2^b	19.3 ± 5.9	77.2 ± 8.1	303.6 ± 15.8^b	172.9 ± 12.7^b	129.8 ± 9.6^b	146.9 ± 11.2^b
HFD-fed
Vehicle-treated	173.4 ± 6.9	53.7 ± 7.0	20.3 ± 6.7	86.3 ± 9.4	422.1 ± 21.3	263.8 ± 14.2	191.7 ± 13.6	223.6 ± 14.2
VBRB (g kg^−1 per day)
0.3	172.3 ± 9.3	41.4 ± 6.7	20.9 ± 6.8	82.4 ±10.2	368.1 ± 16.1^a	228.6 ± 13.5	171.5 ± 13.1	194.3 ± 11.8
0.5	173.1 ± 8.4	30.7 ± 6.9^a	21.8 ± 6.9	80.8 ± 9.7	338.5 ± 22.8^a	198.9 ±13.9^a	156.2 ±10.3^a	170.6 ± 11.0^a
1.0	172.8 ± 6.7	23.6 ± 5.3^b	20.3 ± 6.3	78.1 ± 7.9	308.4 ± 19.2^b	185.3 ± 12.1^b	136.9 ± 8.7^b	151.1 ± 9.2^b
Fenofibrate (100 mg kg^−1 per day)	171.6 ± 8.1	20.4 ± 5.8^b	19.9 ± 7.1	76.7 ± 8.9	293.9 ± 14.6^b	170.2 ± 11.7^b	125.6 ± 9.2^b	142.2 ± 10.5^b

The vehicle (distilled water) used to solve the tested medications was given at the same volume. Values (mean ± SD) were obtained from each group of 8 animals in each group after 12 weeks of the experimental period. ^a𝑃<.05 and ^b𝑃<.01 compared to the values of vehicle-treated HFD-fed rats in each group, respectively.