Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-𝜶 in High-Fat-Diet-Induced Obese Rats

Table 2

Changes in the plasma lipids, hepatic lipids, atherogenic index (AI), and coronary artery index (CRI) in HFD-fed rats receiving 12-weeks treatment with VBRB or fenofibrate.

Groups	Plasma lipids (mg dL^−1)					AI	CRI	Hepatic lipids (μmol g^−1 liver)
	TC	TG	LDL-C	HDL-C	FFAs			TC	TG
RCD-fed
Vehicle-treated	72.9 ± 5.8^b	56.8 ± 6.6^b	31.8 ± 3.2^b	46.9 ± 3.4^b	28.2 ± 2.8^b	0.7 ± 0.3^b	1.6 ± 0.4^b	19.3 ± 2.7^b	24.8 ± 6.2^b
HFD-fed
Vehicle-treated	130.2 ± 12.3	124.5 ± 6.3	120.2 ± 4.2	27.8 ± 3.8	61.9 ± 5.3	4.3 ± 0.2	4.7 ± 0.3	40.2 ± 3.1	54.4 ± 8.4
VBRB (g kg^−1 per day)
0.3	116.7 ± 10.3	110.9 ± 6.8^a	92.5 ± 5.7^a	32.1 ± 4.2^a	55.3 ± 4.6	2.9 ± 0.2^a	3.6 ± 0.3^a	33.9 ± 3.5	48.6 ± 7.9
0.5	99.6 ± 8.3^a	95.0 ± 5.2^a	74.3 ± 5.1^b	39.1 ± 2.9^a	47.1 ± 3.8^a	1.9 ± 0.1^b	2.5 ± 0.3^b	31.7 ± 4.1^a	40.8 ± 7.1
1.0	89.1 ± 7.9^a	80.3 ± 4.8^b	68.1 ± 4.5^b	43.9 ± 3.2^b	38.7 ± 3.2^b	1.5 ± 0.1^b	2.0 ± 0.3^b	26.9 ± 3.8^a	35.2 ± 6.5^a
Fenofibrate (100 mg kg^−1 per day)	80.2 ± 8.0^b	65.6 ± 4.7^b	48.4 ± 4.3^b	45.9 ± 4.4^b	33.2 ± 4.1^b	1.0 ± 0.2^b	1.7 ± 0.4^b	22.4 ± 4.5^b	30.6 ± 7.8^b

The vehicle (distilled water) used to solve the tested medications was given at the same volume. Values (mean ± SD) were obtained from each group of 8 animals in each group after 12 weeks of the experimental period. ^a𝑃<.05 and ^b𝑃<.01 compared to the values of vehicle-treated HFD-fed rats in each group, respectively.