Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Figure 1

Effect of Khat on histological sections of liver and kidney of male and female rats. (a) Normal control of males with normal liver parenchyma, (b) low dose of males with normal liver parenchyma, (c) medium dose of males with normal liver parenchyma, (d) high dose of males with moderate necrotic lesions around the central vein, (e) normal control of females with normal liver parenchyma, (f) low dose of females with normal liver parenchyma, (g) medium dose of females with slight necrotic lesion around the central hepatic vein, (h) high dose of females with a moderate necrotic lesion around the central hepatic vein, (i) normal control of males with normal renal parenchyma, (j) low dose of males with normal renal parenchyma, (k) medium dose of males with normal renal parenchyma, (l) high dose of males with normal renal parenchyma, (m) normal control of females with normal renal parenchyma, (n) low dose of females with mild necrotic lesion in the renal parenchyma, (o) medium dose of females with moderate necrotic lesion in the renal parenchyma, (p) high dose of females with severe necrotic lesions in the renal parenchyma (H & E stain 20x).

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