Evidence-Based Complementary and Alternative Medicine

Research Article

Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Table 4

Renal function test of male SD-rats.


Dose (mg/kg)	Cr (uM/L)	BUN (mM/L)	Na (mM/L)	K (mM/L)	Cl (mM/L)	CO₂ (mM/L)

NC (10 mL/kg)	39.17 ± 2.22	6.05 ± 0.56	143.00 ± 1.53	4.80 ± 0.24	104.67 ± 1.73	22.15 ± 0.41
LD (500 mg/kg)	26.67 ± 2.25*	4.62 ± 0.31	133.67 ± 9.35	4.37 ± 0.35	103.67 ± 6.11	22.07 ± 1.93
MD (1000 mg/kg)	29.17 ± 3.01*	4.25 ± 0.50*	128.17 ± 9.73	4.30 ± 0.23	94.17 ± 6.59	23.50 ± 1.38
HD (2000 mg/kg)	27.17 ± 0.95*	5.63 ± 0.25	142.83 ± 2.44	4.78 ± 0.16	101.17 ± 1.33	24.12 ± 0.78

Cr: creatinine; BUN: urea; Na: Sodium; K: potassium; Cl: chloride; CO₂: carbon dioxide; HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses of crude extract of Khat except NC which received distilled water. The values were expressed as mean ± S.E.M. The superscript (*) indicated a significant difference (P 0.05).