Toxicological Features of Catha edulis (Khat) on Livers and Kidneys of Male and Female Sprague-Dawley Rats: A Subchronic Study

Table 6

Blood film profile of male SD-rats.

Dose (mg/kg)	RBC (×10^12/L)	WBC (×10^9/L)	PLT (×10^9/L)	HGB (g/L)	HCT (L/L)	MCV (fl)	MCH (pg)	MCHC (g/L)
NC (10 mL/kg)	7.80 ± 0.17	7.48 ± 0.46	560.67 ± 97.02	151.67 ± 2.69	7.48 ± 0.46	64.67 ± 0.49	19.50 ± 0.15	303.33 ± 2.03
LD (500 mg/kg)	7.80 ± 0.07	9.98 ± 0.83	757.83 ± 30.83	158.17 ± 1.42	9.98 ± 0.83	64.67 ± 1.28	20.32 ± 0.25	312.17 ± 2.56*
MD (1000 mg/kg)	7.59 ± 0.06	8.48 ± 0.67	770.83 ± 48.22	151.50 ± 1.28	8.48 ± 0.67	64.00 ± 0.56	19.88 ± 0.16	310.67 ± 1.80*
HD (2000 mg/kg)	7.56 ± 0.17	9.23 ± 1.06	613.83 ± 34.22	151.83 ± 2.26	9.23 ± 1.06	64.67 ± 0.92	20.17 ± 0.31	308.00 ± 0.73

RBC: red blood cells; WBC: white blood cells; PLT: platelets; HGB: hemoglobin; HCT: hematocrit; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration; HD: high dose; MD: medium dose; LD: low dose; NC: normal control. The treated groups received different doses of crude extract of khat except NC which received distilled water. The values were expressed as mean ± S.E.M. The superscript (*) indicated a significant difference, P < 0.05.