Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model

Table 2

Effects of oleanolic acid (OA) on the mRNA expression levels of MMP-1, MMP-2, TIMP-1, TGF-𝛽₁, P311, caspase-3, and caspase-9.

Group	Scar (𝑁)	Dose (%)	MMP-1 (%)	MMP-2 (%)	TIMP-1 (%)	Caspase-3 (%)	Caspase-9 (%)	P311 (%)	TGF-𝛽1 (%)
Normal	16	—	0.055±0.010	0.209±0.031	0.011±0.001	0.721±0.084	0.654±0.075	0.121±0.033	0.383±0.083
Control	16	Basic ointment	1.125±0.147^ΔΔ	0.222±0.033	0.054±0.008^ΔΔ	0.441±0.078^ΔΔ	0.431±0.079^ΔΔ	0.436±0.090^ΔΔ	3.248±0.482^ΔΔ
Contra	16	10	0.314±0.047^∗∗	1.589±0.239^∗∗	0.014±0.005^∗∗	1.101±0.165^∗∗	1.266±0.281^∗∗	0.172±0.056^∗∗	0.637±0.134^∗∗
OA	16	2.5	0.676±0.216^∗∗	1.689±0.267^∗∗	0.024±0.009^∗∗	0.621±0.155^∗	0.719±0.195^∗∗	0.298±0.067^∗∗	1.703±0.242^∗∗
OA	16	5	0.302±0.134^∗∗	2.486±0.235^∗∗	0.030±0.002^∗∗	0.907±0.157^∗∗	0.934±0.186^∗∗	0.253±0.049^∗∗	1.481±0.272^∗∗
OA	16	10	0.250±0.063^∗∗	7.014±0.790^∗∗	0.023±0.006^∗∗	1.087±0.134^∗∗	1.368±0.256^∗∗	0.147±0.041^∗∗	0.655±0.157^∗∗

^ΔΔ𝑃<0.01 compared with the normal group; *𝑃 < 0.05 and **𝑃<0.01 compared with the control group; Data are expressed as the mean ± SD.