Alleviation of Morphine Withdrawal Signs but Not Tolerance by the
Essential Oil of Kelussia odoratissima Mozaff.
Figure 3
Effect of (a) acute and (b) chronic administration of different doses of the essential oil of K. odoratissima on the development of morphine tolerance in mice. Mice treated by a single injection of morphine (first day) did not respond to the pain during 15 sec (cut-off time). Morphine was given twice daily over a period of 5 days as described in the method section. In the acute administration different doses of K. odoratissima, nifedipine and vehicle were injected 30 min prior to the last injection of morphine in the morning of the 5th day. In the chronic administration different doses of K. odoratissima, nifedipine and vehicle were injected once a day during morphine injection in the morning for 4 days. Results are the mean (±SEM) from groups of 6 mice. * for comparison with saline + morphine 1st day.
