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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 847167, 8 pages
http://dx.doi.org/10.1155/2012/847167
Research Article

Liuwei Dihuang Lowers Body Weight and Improves Insulin and Leptin Sensitivity in Obese Rats

1Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, PE, Canada C1A 4P3
2Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3
3Department of Chemistry, University of Prince Edward Island, Charlottetown, PE, Canada C1A 4P3
4Department of Nutrition and Food Hygiene, Harbin Medical University, Heilongjiang, Harbin 150081, China

Received 30 January 2011; Revised 14 June 2011; Accepted 23 June 2011

Academic Editor: Vitaly Napadow

Copyright © 2012 Benjamin Perry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. M. Popkin, “The nutrition transition and its health implications in lower-income countries,” Public Health Nutrition, vol. 1, no. 1, pp. 5–21, 1998. View at Google Scholar · View at Scopus
  2. A. Drewnowski and B. M. Popkin, “The nutrition transition: new trends in the global diet,” Nutrition Reviews, vol. 55, no. 2, pp. 31–43, 1997. View at Google Scholar · View at Scopus
  3. A. Must, J. Spadano, E. H. Coakley, A. E. Field, G. Colditz, and W. H. Dietz, “The disease burden associated with overweight and obesity,” Journal of the American Medical Association, vol. 282, no. 16, pp. 1523–1529, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. D. J. Goldstein, “Beneficial health effects of modest weight loss,” International Journal of Obesity, vol. 16, no. 6, pp. 397–415, 1992. View at Google Scholar
  5. S. Fujioka, Y. Matsuzawa, K. Tokunaga et al., “Improvement of glucose and lipid metabolism associated with selective reduction of intra-abdominal visceral fat in premenopausal women with visceral fat obesity,” International Journal of Obesity, vol. 15, no. 12, pp. 853–859, 1991. View at Google Scholar · View at Scopus
  6. A. M. Dattilo and P. M. Kris-Etherton, “Effects of weight reduction on blood lipids and lipoproteins: a meta- analysis,” American Journal of Clinical Nutrition, vol. 56, no. 2, pp. 320–328, 1992. View at Google Scholar · View at Scopus
  7. P. D. Wood, M. L. Stefanick, D. M. Dreon et al., “Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise,” New England Journal of Medicine, vol. 319, no. 18, pp. 1173–1179, 1988. View at Google Scholar · View at Scopus
  8. J. J. Carlson, A. A. Turpin, G. Wiebke, S. C. Hunt, and T. D. Adams, “Pre- and post- prandial appetite hormone levels in normal weight and severely obese women,” Nutrition and Metabolism, vol. 6, article 32, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. S. C. Woods and D. Porte Jr., “Neural control of the endocrine pancreas,” Physiological Reviews, vol. 54, no. 3, pp. 596–619, 1974. View at Google Scholar · View at Scopus
  10. A. Abizaid and T. L. Horvath, “Brain circuits regulating energy homeostasis,” Regulatory Peptides, vol. 149, no. 1–3, pp. 3–10, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. F. Davis, D. L. Choi, and S. C. Benoit, “Insulin, leptin and reward,” Trends in Endocrinology and Metabolism, vol. 21, no. 2, pp. 68–74, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. L. Halaas, K. S. Gajiwala, M. Maffei et al., “Weight-reducing effects of the plasma protein encoded by the obese gene,” Science, vol. 269, no. 5223, pp. 543–546, 1995. View at Google Scholar · View at Scopus
  13. M. W. Schwartz and K. D. Niswender, “Adiposity signaling and biological defense against weight gain: absence of protection or central hormone resistance?” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 12, pp. 5889–5897, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. B. Carlsson, K. Lindell, B. Gabrielsson et al., “Obese (ob) gene defects are rare in human obesity,” Obesity Research, vol. 5, no. 1, pp. 30–35, 1997. View at Google Scholar
  15. G. I. Shulman, “Cellular mechanisms of insulin resistance,” Journal of Clinical Investigation, vol. 106, no. 2, pp. 171–176, 2000. View at Google Scholar · View at Scopus
  16. N. Stefan, B. Vozarova, T. Funahashi et al., “Plasma adiponectin concentration is associated with skeletal muscle insulin receptor tyrosine phosphorylation, and low plasma concentration precedes a decrease in whole-body insulin sensitivity in humans,” Diabetes, vol. 51, no. 6, pp. 1884–1888, 2002. View at Google Scholar · View at Scopus
  17. D. C. Klonoff and F. Greenway, “Drugs in the pipeline for the obesity market,” Journal of Diabetes Science and Technology, vol. 2, no. 5, pp. 913–918, 2008. View at Google Scholar
  18. B. Xie, T. Gong, M. Tang et al., “An approach based on HPLC-fingerprint and chemometrics to quality consistency evaluation of Liuwei Dihuang Pills produced by different manufacturers,” Journal of Pharmaceutical and Biomedical Analysis, vol. 48, no. 4, pp. 1261–1266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. X. Zhao, Y. Wang, and Y. Sun, “Quantitative and qualitative determination of Liuwei Dihuang tablets by HPLC-UV-MS-MS,” Journal of Chromatographic Science, vol. 45, no. 8, pp. 549–552, 2007. View at Google Scholar · View at Scopus
  20. H. Y. Fu, S. Y. Huan, L. Xu et al., “Construction of an efficacious model for a nondestructive identification of traditional Chinese medicines Liuwei Dihuang pills from different manufacturers using near-infrared spectroscopy and moving window partial least-squares discriminant analysis,” Analytical Sciences, vol. 25, no. 9, pp. 1143–1148, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Ye, X. Zhang, W. Dai et al., “Chemical fingerprinting of Liuwei Dihuang Pill and simultaneous determination of its major bioactive constituents by HPLC coupled with multiple detections of DAD, ELSD and ESI-MS,” Journal of Pharmaceutical and Biomedical Analysis, vol. 49, no. 3, pp. 638–645, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. M. Xue, R. Luo, B. Zhu, Y. Zhang, Y. H. Pan, and C. Z. Li, “Effects of Liuwei Dihuang pills on expressions of apoptosis-related genes bcl-2 and Bax in pancreas of OLETF rats,” Zhong Xi Yi Jie He Xue Bao, vol. 3, no. 6, pp. 455–458, 2005. View at Google Scholar · View at Scopus
  23. Y. Wang, X. Jia, K. Ghanam, C. Beaurepaire, J. Zidichouski, and L. Miller, “Berberine and plant stanols synergistically inhibit cholesterol absorption in hamsters,” Atherosclerosis, vol. 209, no. 1, pp. 111–117, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Gao, K. P. Kinzig, S. Aja et al., “Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 44, pp. 17358–17363, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. G. Yuan, K. Z. Al-Shali, and R. A. Hegele, “Hypertriglyceridemia: its etiology, effects and treatment,” Canadian Medical Association Journal, vol. 176, no. 8, pp. 1113–1120, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. G. Boden, “Free fatty acids (FFA), a link between obesity and insulin resistance,” Frontiers in Bioscience, vol. 3, pp. d169–d175, 1998. View at Google Scholar · View at Scopus
  27. R. E. Andersen, T. A. Wadden, S. J. Bartlett, R. A. Vogt, and R. S. Weinstock, “Relation of weight loss to changes in serum lipids and lipoproteins in obese women,” American Journal of Clinical Nutrition, vol. 62, no. 2, pp. 350–357, 1995. View at Google Scholar · View at Scopus
  28. Y. Ishii, J. E. Blundell, J. C. Halford, and R. J. Rodgers, “Palatability, food intake and the behavioural satiety sequence in male rats,” Physiology and Behavior, vol. 80, no. 1, pp. 37–47, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. C. B. Saper, T. C. Chou, and J. K. Elmquist, “The need to feed: homeostatic and hedonic control of eating,” Neuron, vol. 36, no. 2, pp. 199–211, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. S. J. Hu, Q. Fang, J. S. Liu, L. Zhang, and E. Z. Cao, “Clinical study on intervention of Liuwei Dihuang Pill on hormonotherapy in treating nephrotic syndrome,” Zhongguo Zhong Xi Yi Jie He Za Zhi, vol. 25, no. 2, pp. 107–110, 2005. View at Google Scholar · View at Scopus
  31. W. Insull Jr., D. Black, C. Dujovne et al., “Efficacy and safety of once-daily vs twice-daily dosing with fluvastatin, a synthetic reductase inhibitor, in primary hypercholesterolemia,” Archives of Internal Medicine, vol. 154, no. 21, pp. 2449–2455, 1994. View at Publisher · View at Google Scholar · View at Scopus
  32. G. H. Ross, L. B. Hovde, K. H. Ibrahim, Y. H. Ibrahim, and J. C. Rotschafer, “Comparison of once-daily versus twice-daily administration of cefdinir against typical bacterial respiratory tract pathogens,” Antimicrobial Agents and Chemotherapy, vol. 45, no. 10, pp. 2936–2938, 2001. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Cusi, “The role of adipose tissue and lipotoxicity in the pathogenesis of type 2 diabetes,” Current Diabetes Reports, vol. 10, no. 4, pp. 306–315, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S. E. Kahn, R. L. Hull, and K. M. Utzschneider, “Mechanisms linking obesity to insulin resistance and type 2 diabetes,” Nature, vol. 444, no. 7121, pp. 840–846, 2006. View at Publisher · View at Google Scholar · View at Scopus
  35. A. Golay, A. L. Swislocki, Y. D. Chen, J. B. Jaspan, and G. M. Reaven, “Effect of obesity on ambient plasma glucose, free fatty acid, insulin, growth hormone, and glucagon concentrations,” Journal of Clinical Endocrinology and Metabolism, vol. 63, no. 2, pp. 481–484, 1986. View at Google Scholar
  36. T. McLaughlin, F. Abbasi, C. Lamendola, H. S. Kim, and G. M. Reaven, “Metabolic changes following sibutramine-assisted weight loss in obese individuals: role of plasma free fatty acids in the insulin resistance of obesity,” Metabolism, vol. 50, no. 7, pp. 819–824, 2001. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Gil-Campos, R. Canete, and A. Gil, “Hormones regulating lipid metabolism and plasma lipids in childhood obesity,” International Journal of Obesity, vol. 28, supplement 3, pp. S75–S80, 2004. View at Publisher · View at Google Scholar
  38. M. Matsubara, S. Maruoka, and S. Katayose, “Inverse relationship between plasma adiponectin and leptin concentrations in normal-weight and obese women,” European Journal of Endocrinology, vol. 147, no. 2, pp. 173–180, 2002. View at Google Scholar · View at Scopus
  39. S. K. Fried, M. R. Ricci, C. D. Russell, and B. Laferrere, “Regulation of leptin production in humans,” Journal of Nutrition, vol. 130, no. 12, pp. 3127S–3131S, 2000. View at Google Scholar · View at Scopus
  40. R. Matyskova, B. Zelezna, J. Maixnerova, D. Koutova, M. Haluzik, and L. Maletinska, “Estradiol supplementation helps overcome central leptin resistance of ovariectomized mice on a high fat diet,” Hormone and Metabolic Research, vol. 42, no. 3, pp. 182–186, 2010. View at Publisher · View at Google Scholar
  41. R. C. Frederich, A. Hamann, S. Anderson, B. Lollmann, B. B. Lowell, and J. S. Flier, “Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action,” Nature Medicine, vol. 1, no. 12, pp. 1311–1314, 1995. View at Google Scholar · View at Scopus
  42. M. Nannipieri, C. Gonzales, S. Baldi et al., “Liver enzymes, the metabolic syndrome, and incident diabetes: the Mexico City diabetes study,” Diabetes Care, vol. 28, no. 7, pp. 1757–1762, 2005. View at Publisher · View at Google Scholar · View at Scopus
  43. V. Messier, A. D. Karelis, M. E. Robillard et al., “Metabolically healthy but obese individuals: relationship with hepatic enzymes,” Metabolism, vol. 59, no. 1, pp. 20–24, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. A. J. Hanley, K. Williams, A. Festa, L. E. Wagenknecht, R. B. D'Agostino Jr., and S. M. Haffner, “Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study,” Diabetes, vol. 54, no. 11, pp. 3140–3147, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. C. Thamer, O. Tschritter, M. Haap et al., “Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids,” Hormone and Metabolic Research, vol. 37, no. 4, pp. 246–251, 2005. View at Publisher · View at Google Scholar · View at Scopus