Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9, -3/7 Activation, and NF-κB Inhibition

Table 3

Renal function test. Male and female rats received vehicle (CMC), 100 mg/kg or 1000 mg/kg dentatin for 14 days. Renal function was examined by measuring serum level of sodium, potassium, chloride, CO₂, anion gap, urea and creatinine.

Dose	Sodium (mmol/L)	Potassium (mmol/L)	Chloride (mmol/L)	CO2  (mmol/L)	Anion gap (mmol/L)	Urea (mmol/L)	Creatinine (μmol/L)
Male rats (𝑛=6)
Vehicle (CMC)	142.05 ± 3.58	4.89 ± 0.07	104.01 ± 2.87	24.85 ± 1.85	18.11 ± 0.58	5.50 ± 0.38	34.88 ± 2.38
Dentatin 100 mg/kg	142.03 ± 2.54	5.00 ± 0.06	107.13 ± 2.03	22.60 ± 1.19	18.17 ± 0.61	6.20 ± 0.20	33.67 ± 2.65
Dentatin 1000 mg/kg	144.50 ± 3.86	4.95 ± 0.05	105.17 ± 2.58	21.56 ± 1.05	17.32 ± 0.45	5.63 ± 0.39	36.13 ± 4.90
Female rats (𝑛=6)
Vehicle (CMC)	141.53 ± 4.410	4.66 ± 0.12	105.38 ± 2.67	23.38 ± 1.47	18.01 ± 0.86	7.98 ± 0.35	41.89 ± 3.75
Dentatin 100 mg/kg	141.00 ± 3.68	4.75 ± 0.16	107.53 ± 3.68	22.95 ± 0.95	17.13 ± 1.71	8.11 ± 0.24	42.34 ± 4.76
Dentatin 1000 mg/kg	142.27 ± 4.47	4.54 ± 0.13	106.00 ± 3.63	22.58 ± 1.78	18.17 ± 1.49	8.31 ± 0.69	44.05 ± 2.15