Anticonvulsant Activity of Extracts of Plectranthus barbatus Leaves in Mice

Table 1

Anticonvulsant effect of Plecthranthus barbatus leaf extracts on strychnine-induced seizures in mice.

Dose (mg/kg) p.o.	Time to seizure onset (s)	Death latency (s)	Death rate (%)
0 (control)	217 ± 23.9	282.0 ± 46.7	100
1	461.3 ± 68.1*	518.8 ± 48.6*	100
10	236.4 ± 51.3	353.0 ± 46.7	100
30	317.4 ± 45.4	452.3 ± 52.6	87.5
100	no seizures	no seizures	0

* 𝑃<.05, compared to control (ANOVA followed by Dunnett’s multiple comparisons test).