Antinociceptive Activity of Methanol Extract of Muntingia calabura Leaves and the Mechanisms of Action Involved
Figure 2
Effect of MEMC in formalin-induced paw licking test. Graph A shows early phase activity, while graph B shows the late phase analgesic effect. Each column represents the mean ± SEM of 6 rats. The rats were pretreated with vehicle (10% DMSO), MEMC (100, 250, and 500 mg/kg, p.o.), acetylsalicylic acid (ASA, p.o.), or morphine (5 mg/kg, p.o.), 60 min before i.pl injection of formalin. The asterisks denote the significance levels as compared to control, *** by one-way ANOVA followed by Dunnett’s post hoc test. ***Data differed significantly () when compared to the 10% DMSO-treated group.
