Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 892182, 8 pages
http://dx.doi.org/10.1155/2012/892182
Research Article

Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial

1Departamento de Química, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
2Hospital Universitário de Santa Maria, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
3Departamento de Biologia, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
4Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil
5Departamento de Morfologia, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil

Received 26 March 2011; Revised 18 June 2011; Accepted 23 June 2011

Academic Editor: Angelo Antonio Izzo

Copyright © 2012 I. L. G. Farias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. André, C. Boni, L. Mounedji-Boudiaf et al., “Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer,” New England Journal of Medicine, vol. 350, no. 23, pp. 2343–2351, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Kusmartsev and D. I. Gabrilovich, “Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species,” Journal of Leukocyte Biology, vol. 74, no. 2, pp. 186–196, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Mena, A. Ortega, and J. M. Estrela, “Oxidative stress in environmental-induced carcinogenesis,” Mutation Research, vol. 674, no. 1-2, pp. 36–44, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. T. N. Seyfried and L. M. Shelton, “Cancer as a metabolic disease,” Nutrition and Metabolism, vol. 7, article 7, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. J. Alexandre, Y. Hu, W. Lu, H. Pelicano, and P. Huang, “Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species,” Cancer Research, vol. 67, no. 8, pp. 3512–3517, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. A. C. P. Diederichsen, J. V. B. Hjelmborg, P. B. Christensen, J. Zeuthen, and C. Fenge, “Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells,” Cancer Immunology, Immunotherapy, vol. 52, no. 7, pp. 423–428, 2003. View at Publisher · View at Google Scholar
  7. J. Vincent, G. Mignot, F. Chalmin et al., “5-Fluorouracil selectively kills tumor-associated myeloid-derived suppressor cells resulting in enhanced T cell-dependent antitumor immunity,” Cancer Research, vol. 70, no. 8, pp. 3052–3061, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. M. Klemke and Y. Samstag, “Molecular mechanisms mediating oxidative stress-induced T-cell suppression in cancer,” Advances in Enzyme Regulation, vol. 49, no. 1, pp. 107–112, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. M. L. Janssen, C. B. Bosman, C. F. M. Sier et al., “Superoxide dismutases in relation to the overall survival of colorectal cancer patients,” British Journal of Cancer, vol. 78, no. 8, pp. 1051–1057, 1998. View at Google Scholar · View at Scopus
  10. R. Pilarski, H. Zieliński, D. Ciesiołka, and K. Gulewicz, “Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC,” Journal of Ethnopharmacology, vol. 104, no. 1-2, pp. 18–23, 2006. View at Publisher · View at Google Scholar · View at Scopus
  11. Y. Sheng, L. Li, K. Holmgren, and R. W. Pero, “DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study,” Phytomedicine, vol. 8, no. 4, pp. 275–282, 2001. View at Google Scholar · View at Scopus
  12. S. Eberlin, L. M. B. Dos Santos, and M. L. S. Queiroz, “Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes,” International Immunopharmacology, vol. 5, no. 7-8, pp. 1235–1246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. Sheng, C. Bryngelsson, and R. W. Pero, “Enhanced DNA repair, immune function and reduced toxicity of C-MED, a novel aqueous extract from Uncaria tomentosa,” Journal of Ethnopharmacology, vol. 69, no. 2, pp. 115–126, 2000. View at Publisher · View at Google Scholar · View at Scopus
  14. Y. Sheng, R. W. Pero, and H. Wagner, “Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa,” Phytomedicine, vol. 7, no. 2, pp. 137–143, 2000. View at Google Scholar · View at Scopus
  15. R. S. Greenberg, S. R. Daniels, W. D. Flanders, J. W. Eley, and J. R. Boring, “Appendix A: estimation of sample size requirements for randomized controlled clinical trials,” in Medical Epidemiology, McGraw-Hill, Columbia, SC, USA, 4th edition, 2004. View at Google Scholar
  16. R. L. Levine, D. Garland, C. N. Oliver et al., “Determination of carbonyl content in oxidatively modified proteins,” Methods in Enzymology, vol. 186, pp. 464–478, 1990. View at Publisher · View at Google Scholar · View at Scopus
  17. A. M. Jentzsch, H. Bachmann, P. Fürst, and H. K. Biesalski, “Improved analysis of malondialdehyde in human body fluids,” Free Radical Biology and Medicine, vol. 20, no. 2, pp. 251–256, 1996. View at Publisher · View at Google Scholar · View at Scopus
  18. D. P. Nelson and L. A. Kiesow, “Enthalpy of decomposition of hydrogen peroxide by catalase at 25 C (with molar extinction coefficients of H2O2 solutions in the UV),” Analytical Biochemistry, vol. 49, no. 2, pp. 474–478, 1972. View at Google Scholar · View at Scopus
  19. J. M. McCord and I. Fridovich, “Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein),” Journal of Biological Chemistry, vol. 244, no. 22, pp. 6049–6055, 1969. View at Google Scholar · View at Scopus
  20. Y. S. Taktak, S. Selkirk, A. F. Bristow et al., “Assay of pyrogens by interleukin-6 release from monocytic cell lines,” Journal of Pharmacy and Pharmacology, vol. 43, no. 8, pp. 578–582, 1991. View at Google Scholar · View at Scopus
  21. N. P. Singh, M. T. McCoy, R. R. Tice, and E. L. Schneider, “A simple technique for quantitation of low levels of DNA damage in individual cells,” Experimental Cell Research, vol. 175, no. 1, pp. 184–191, 1988. View at Google Scholar · View at Scopus
  22. National Cancer Institute (NCI), “Common Toxicity Criteria,” 2010, http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf.
  23. R. Gerson-Cwillich, A. Serrano-Olvera, and A. Villalobos-Prieto, “Complementary and alternative medicine (CAM) in Mexican patients with cancer,” Clinical and Translational Oncology, vol. 8, no. 3, pp. 200–207, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. Z. Chen, K. Gu, Y. Zheng, W. Zheng, W. Lu, and X. O. Shu, “The use of complementary and alternative medicine among Chinese women with breast cancer,” Journal of Alternative and Complementary Medicine, vol. 14, no. 8, pp. 1049–1055, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Sparber, L. Bauer, G. Curt et al., “Use of complementary medicine by adult patients participating in cancer clinical trials,” Oncology Nursing Forum, vol. 27, no. 4, pp. 623–630, 2000. View at Google Scholar · View at Scopus
  26. L. K. Helyer, S. Chin, B. K. Chui et al., “The use of complementary and alternative medicines among patients with locally advanced breast cancer—a descriptive study,” BMC Cancer, vol. 6, article 39, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. A. Montazeri, A. Sajadian, M. Ebrahimi, S. Haghighat, and I. Harirchi, “Factors predicting the use of complementary and alternative therapies among cancer patients in Iran,” European Journal of Cancer Care, vol. 16, no. 2, pp. 144–149, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. U. Werneke, D. Ladenheim, and T. McCarthy, “Complementary alternative medicine for cancer: a review of effectiveness and safety,” Cancer Therapy, vol. 2, pp. 475–500, 2004. View at Google Scholar
  29. C. Akesson, R. W. Pero, and F. Ivars, “C-Med 100, a hot water extract of Uncaria tomentosa, prolongs lymphocyte survival in vivo,” Phytomedicine, vol. 10, no. 1, pp. 23–33, 2003. View at Publisher · View at Google Scholar · View at Scopus
  30. C. Gonçalves, T. Dinis, and M. T. Batista, “Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity,” Phytochemistry, vol. 66, no. 1, pp. 89–98, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. R. Paniagua-Pérez, E. Madrigal-Bujaidar, D. Molina-Jasso et al., “Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine,” Basic and Clinical Pharmacology and Toxicology, vol. 104, no. 3, pp. 222–227, 2009. View at Publisher · View at Google Scholar
  32. S. Amaral, L. Mira, J. M. F. Nogueira, A. P. D. Silva, and M. Helena Florêncio, “Plant extracts with anti-inflammatory properties—a new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships,” Bioorganic and Medicinal Chemistry, vol. 17, no. 5, pp. 1876–1883, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. C. Desmarchelier, E. Mongelli, J. Coussio, and G. Ciccia, “Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.) DC,” Phytotherapy Research, vol. 11, no. 3, pp. 254–256, 1997. View at Google Scholar · View at Scopus
  34. Y. Sheng, C. Åkesson, K. Holmgren, C. Bryngelsson, V. Giamapa, and R. W. Pero, “An active ingredient of Cat's claw water extracts: identification and efficacy of quinic acid,” Journal of Ethnopharmacology, vol. 96, no. 3, pp. 577–584, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. I. Lemaire, V. Assinewe, P. Cano, D. V. C. Awang, and J. T. Arnason, “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Una de Gato),” Journal of Ethnopharmacology, vol. 64, no. 2, pp. 109–115, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. J. Piscoya, Z. Rodriguez, S. A. Bustamante, N. N. Okuhama, M. J. S. Miller, and M. Sandoval, “Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis,” Inflammation Research, vol. 50, no. 9, pp. 442–448, 2001. View at Google Scholar · View at Scopus
  37. National Center for Complementary and Alternative Medicine, National Institutes of Health, “Herbs at a glance/Cat’s Claw,” 2011, http://nccam.nih.gov/health/catclaw/.