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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 894509, 7 pages
Research Article

Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress: A Double-Blind, Placebo-Controlled Study

1Clinical Pharmacology, OP Chaudhry Hospital and Research Centre, Lucknow 226 015, India
2General Medicine and Cardiology, Lucknow 226 001, India
3General Medicine, Bhatnagar Nursing Home, Lucknow 226 012, India
4Statistics Centre, Institute for Data Computing and Training, Lucknow 226 012, India
5Sannidhi, Gurgaon, India
6Research and Development Centre, Natural Remedies, Karnataka, Bangalore 560 100, India

Received 20 April 2011; Accepted 12 July 2011

Academic Editor: José Luis Ríos

Copyright © 2012 Ram Chandra Saxena et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of OciBest, an extract of Ocimum tenuiflorum Linn. in symptomatic control of general stress. The participants received either placebo () or OciBest (; 1200 mg of actives per day) for six weeks. The severity of stress-related symptoms was self-evaluated by patients at weeks 0, 2, 4 and 6 of the trial period using a symptom rating scale. After six weeks of intervention, scores of symptoms such as forgetfulness, sexual problems of recent origin, frequent feeling of exhaustion, and frequent sleep problems of recent origin decreased significantly () in OciBest group as compared with placebo group. Also, the total symptom scores of OciBest group revealed significant reduction () as compared to placebo group. The overall improvement in OciBest group was found to be 1.6 times or 39% more in the control of general stress symptoms with respect to placebo. No adverse events were reported during the study. The findings revealed that OciBest was found to be effective and well tolerated by all the patients over the six weeks of study period.