Hepatoprotective Potential of Caesalpinia crista against Iron-Overload-Induced Liver Toxicity in Mice
Figure 6
Histopathology. Photomicrograph of mice liver sections (staining with haematoxylin and eosin) ×40; (a) normal mice liver. (b) Iron-intoxicated (iron dextran, 100 mg/kg b.w.) liver section showing necrosis (N), fatty ballooning degeneration (FD), inflammation (I), and loss of cellular boundaries. (c) Liver section treated with iron dextran +50 mg/kg b.w. CCME showing improved histology with portal inflammation (PI). (d) Liver section treated with iron dextran +100 mg/kg b.w. CCME. (e) Liver section treated with iron dextran +200 mg/kg b.w. CCME. The two groups (d) and (e) show reduced hepatocellular necrosis, ballooning degeneration, and inflammation. (f) Liver section treated with iron dextran +20 mg/kg b.w. desirox also shows reduced necrotic area and increased number of hepatocytes.
