Copaiba Oil: An Alternative to Development of New Drugs against Leishmaniasis

Figure 2

Ultrastructural effect of copaiba oil after incubation for 72 h on promastigote and axenic amastigote forms of L. amazonensis, observed by transmission electron microscopy. (a) promastigote control; (b) promastigote treated with IC₅₀ of copaiba oil; (c and d) promastigote treated with IC₉₀ of copaiba oil; (e) amastigote, control; (f) amastigote treated with IC₅₀ of copaiba oil; (g and h) amastigote treated with IC₉₀ of copaiba oil. Bars = 1 μm. The treatment with copaiba oil led to changes in the mitochondria (m), exocytic activity in the region of the flagellar pocket (asterisk), and cytoplasmic vacuolisation (white star). n, nucleus; f, flagellum; fp, flagellar pocket; k, kinetoplast; m, mitochondrion.

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