Hesperidin-3′-O-Methylether Is More Potent than Hesperidin in Phosphodiesterase Inhibition and Suppression of Ovalbumin-Induced Airway Hyperresponsiveness

Figure 5

Effects of orally administered hesperidin (a, b, and c) and hesperidin-3′-O-methylether (d, e, and f) on the enhanced pause (𝑃_enh, a, d), inflammatory cells (b, e), and cytokines (c, f) in sensitized mice which received aerosolized methacholine (6.25~50 mg/mL) 2 days after the last allergen challenge. ^#𝑃<0.05, ^##𝑃<0.01, and ^###𝑃<0.001, compared to the nonchallenged group. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001, compared to the control (vehicle) group. The number of mice in each group was 10. Total, total cells; Mac: macrophages; Lym: lymphocytes; Neu: neutrophils; Eos: eosinophils; IL: interleukin; IF: interferon; TNF: tumor necrosis factor.