Topical Apigenin Alleviates Cutaneous Inflammation in Murine Models

Figure 2

Topical applications of apigenin reduce edema in acute murine dermatitis models. Acute irritant contact dermatitis and allergic contact dermatitis models were established as described in Materials and Methods Ear samples for H&E staining were taken immediately after measurements of ear thickness. (a) and (d) are normal ears. (b) and (c) are acute allergic contact dermatitis (AACD) treated with vehicle and apigenin, respectively. (e) and (f) are acute irritant contact dermatitis (AICD) treated with vehicle and apigenin, respectively. A remarkable reduction in ear thickness and edema were evident in apigenin-treated ear. The magnifications for all images are the same. Scale bar = 50 μm.