Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 4

Research Article

Copaiba Oil-Resin Treatment Is Neuroprotective and Reduces Neutrophil Recruitment and Microglia Activation after Motor Cortex Excitotoxic Injury

Figure 4

COR treatment reduces mononuclear cell infiltration at 4 days following cortical damage, as revealed by anti-ED1 immunohistochemistry. Animals treated with 5% tween (a-b) or 400 mg/kg of COR (c-d). COR treatment reduced microglia/macrophage activation (ED1+ cells) (c-d), compared to vehicle animals (a-b), as confirmed by quantitative analysis (e, , Student’s t-test). Arrows point to ED1+ cells (activated microglia/macrophages). Asterisks indicate the excitotoxic necrotic center. Scale bars: (a–c) (300 μm); (b–d) (50 μm).

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