Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide and Mucuna macrocarpa Stem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism

Table 1

CI values for the combination of ATO and CMEMM in leukemia cell lines after 24 h of treatment.

Drug combination		Cell line
ATO	CMEMM	HL-60		Jurkat		Molt-3
(μM)	(μg/mL)	CI	Description	CI	Description	CI	Description
2.5	25	0.644	Synergism	1.043	Nearly additive	0.772	Moderate synergism
2.5	50	0.683	Synergism	0.802	Moderate synergism	0.935	Nearly additive
2.5	75	0.888	Slight synergism	0.820	Moderate synergism	1.155	Slight antagonism
5	25	0.887	Slight synergism	1.446	Moderate antagonism	0.852	Slight synergism
5	50	0.610	Synergism	0.868	Slight synergism	0.850	Moderate synergism
5	75	0.843	Moderate synergism	0.899	Slight synergism	1.021	Nearly additive

CI: combination index; ATO: arsenic trioxide; CMEMM: crude methanolic extract of Mucuna macrocarpa.