Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 5

Research Article

Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus

Figure 5

Mouse protection against lethal JEV challenge by I. indigotica. Groups of 2-week-old BALB/c mice were intracerebrally infected with JEV at 1 × 105 pfu, then underwent three intracerebral treatments with I. indigotica extract, indigo, or indirubin (1 mg/kg of body weight) at 2, 24, and 48 h after infection. Two additional groups were infected with JEV and received PBS or DMSO (0.05%) treatment as solvent controls. Survival rates were monitored daily.

We are committed to sharing findings related to COVID-19 as quickly and safely as possible. Any author submitting a COVID-19 paper should notify us at help@hindawi.com to ensure their research is fast-tracked and made available on a preprint server as soon as possible. We will be providing unlimited waivers of publication charges for accepted articles related to COVID-19.