Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus
Figure 5
Mouse protection against lethal JEV challenge by I. indigotica. Groups of 2-week-old BALB/c mice were intracerebrally infected with JEV at 1 × 105 pfu, then underwent three intracerebral treatments with I. indigotica extract, indigo, or indirubin (1 mg/kg of body weight) at 2, 24, and 48 h after infection. Two additional groups were infected with JEV and received PBS or DMSO (0.05%) treatment as solvent controls. Survival rates were monitored daily.
