Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis

Figure 5

Tanshinone IIA induces apoptosis in mouse keratinocytes. Detection of tanshinone IIA-induced apoptosis and necrosis was measured by (a) flow cytometry after Hoechst 33324/PI staining. (b) Graph represents means ± SD of percent of apoptotic cells of flow cytometry results. (c) Detection of tanshinone IIA-induced apoptosis with Apo-BrdU staining followed by flow cytometry. Asterisk marks indicate a significant difference between control and tanshinone IIA-treated cells (*𝑃<0.05, **𝑃<0.01).

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