Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis

<table>Effects of Ac-DEVD-CHO on tanshinone IIA-induced apoptosis in keratinocytes. Apoptosis was determined by Apo-BrdU staining. Ac-DEVD-CHO attenuated tanshinone IIA-induced apoptosis, indicating that tanshinone IIA causes apoptosis by a caspase-dependent pathway. The asterisk indicates a significant difference between control and tanshinone IIA-treated cells (*<svg height="11.375" id="M33" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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Evidence-Based Complementary and Alternative Medicine

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Figure 8

Figure 8: Tanshinone IIA Inhibits Growth of Keratinocytes through Cell Cycle Arrest and Apoptosis: Underlying Treatment Mechanism of Psoriasis 