Chinese Herbal Formula Xiao Yao San for Treatment of Depression: A Systematic Review of Randomized Controlled Trials

Table 1

Characteristics and methodological quality of included studies.

Study ID	Sample	Diagnosis standard	Intervention	Control	Course (week)	Followup (month)	Outcome measure
Du et al. [8]	120	CCMD-3	xiaoyao pill plus fluoxetine	amitriptyline paroxetine	6–8		HAMD and TESS score, side effect
Huang and Gan [9]	69	ICD-10	Shugan jieyu formula	amitriptyline	6		clinical effect, side effect
Huo et al. [10]	72	CCMD-3	danzhi xiaoyao decoction plus fluoxetine	fluoxetine	6		clinical effect, HAMD, HAMA and CJI score, side effect
J. Li et al. [11]	60	CCMD-3	xiaoyao pill plus imipramine	imipramine	8		clinical effect, HAMD score, side effect
Y. J. Li et al. [12]	66	CCMD-3, ICD-10	danzhixiaoyao powder	maprotiline	6		HAMD score, 5-HT, NE, EDNF, CORT, IL-6, IL-1β
H. Li et al. [13]	80	Unclear	xiaoyao powder plus fluoxetine	fluoxetine	6	12	clinical effect, HAMD, SDS score, side effect
Liu and Chen 2007 [14]	78	“practice of internal medicine”-3	danzhixiaoyao powder plus amitriptyline	amitriptyline	8		clinical effect, HAMD score
Luo et al. 2006 [15]	66	CCMD-3, ICD-10	danzhixiaoyao powder	maprotiline	6		symptoms, clinical effect, HAMD, SDS, SAS and Asberg score, side effect
Ma 2007 [16]	60	CCMD-3	xiaoyao pill plus citalopram	citalopram	8	12	clinical effect, HAMD and Tess score, side effect
C. Y. Wang et al. 2004 [17]	200	CCMD-2-R	guipi xiaoyao pill	venlafaxine	4		clinical effect, SDS score, side effect
R. C. Wang 2008 [18]	60	CCMD-3	modifiedxiaoyao powder	amitriptyline	6		clinical effect, HAMD score, side effect
T. Y. Wang 2001 [19]	61	CCMD-2-R ICD-10	danzhixiaoyao decoction	fluoxetine	6		clinical effect, SDS score, side effect
W. A. Wang et al. 2005 [20]	68	CCMD-3	xiaoyao pill plus doxepin	fluoxetine	6		clinical effect, HAMD and HAMA score, side effect
Y. Wang and Liu [21]	60	CCMD-3	danzhixiaoyao powder plus fluoxetine	fluoxetine	8		clinical effect, HAMD and CGI-SI score, side effect
Wei et al. 1999 [22]	60	CCMD-2-R	xiaoyao powder plus amitriptyline	amitriptyline	4		clinical effect
Xian et al. [23]	60	CCMD-3	xiaoyao powder	fluoxetine	6		symptoms, clinical effect, HAMD score
Xiao [24]	66	CCMD-3	danzhixiaoyao powder plus clomipramine	clomipramine	8		clinical effect
Yang and Xie [25]	58	CCMD-2	xiaoyao powder plus amitriptyline or clomipramine	amitriptyline or clomipramine	12		clinical effect, TESS score, side effect
Yang et al. [26]	64	CCMD-3	modified xiaoyao pill plus amitriptyline	fluoxetine	12	3	clinical effect, HAMD score, side effect
Zhai et al. [7]	24	CCMD-2-R	xiaoyao powder plus doxepin	doxepin	8		clinical effect, HAMD and TESS score, side effect
Zhang et al. [27]	59	CCMD-3	xiaoyao pill plus fluoxetine	fluoxetine	6		clinical effect, HAMD and TESS score, side effect
Zhang [28]	50	CCMD-3	xiaoyao pill plus fluoxetine	fluoxetine	6		HAMD score, side effect
Zhao and Jiang [29]	66	CCMD-3	modified xiaoyao powder plus amitriptyline	amitriptyline	12		symptoms, clinical effect, HAMD score, side effect
Zhou and Li [30]	90	CCMD-3	xiaoyao powder	fluoxetine	8		symptoms, clinical effect, HAMD and SDS score, side effect
Zhu [31]	60	CCMD-2	xiaoyao pill plus venlafaxine	venlafaxine	10		HAMD score, side effect
Zhu and Li [32]	60	CCMD-2	xiaoyao powder plus amitriptyline	amitriptyline	8		clinical effect, side effect