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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 932165, 8 pages
Research Article

Ginsenoside-Rg1 Protects the Liver against Exhaustive Exercise-Induced Oxidative Stress in Rats

1Laboratory of Exercise Biochemistry, Department of Sports Sciences, Taipei Physical Education College, Taipei 11153, Taiwan
2Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan
3Graduate Institute of Chinese Medicine, China Medical University, Taichung 40402, Taiwan
4The Chest Department, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei 112, Taiwan
5Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung 40402, Taiwan

Received 2 May 2011; Accepted 29 June 2011

Academic Editor: S. Nagini

Copyright © 2012 Mallikarjuna Korivi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Despite regular exercise benefits, acute exhaustive exercise elicits oxidative damage in liver. The present study determined the hepatoprotective properties of ginsenoside-Rg1 against exhaustive exercise-induced oxidative stress in rats. Forty rats were assigned into vehicle and ginsenoside-Rg1 groups (0.1 mg/kg bodyweight). After 10-week treatment, ten rats from each group performed exhaustive swimming. Estimated oxidative damage markers, including thiobarbituric acid reactive substance (TBARS) (67%) and protein carbonyls (56%), were significantly ( ) elevated after exhaustive exercise but alleviated in ginsenoside-Rg1 pretreated rats. Furthermore, exhaustive exercise drastically decreased glutathione (GSH) content (~79%) with concurrent decreased superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities. However, these changes were attenuated in Rg1 group. Additionally, increased xanthine oxidase (XO) activity and nitric oxide (NO) levels after exercise were also inhibited by Rg1 pretreatment. For the first time, our findings provide strong evidence that ginsenoside-Rg1 can protect the liver against exhaustive exercise-induced oxidative damage.