Figure 3: APP immunohistochemistry in the hippocampus and ischemic cortex seven days after tMCAo. (a) The region within the rectangular dotted line indicates the CA1 sector, and the region within the square dotted line indicates the MCA territory of cortex, for calculation of APP-immunopositive cells. (b) Representative photographs showing APP immunoreactivity in the hippocampal CA1 area. (c) APP-positive cells per 400X microscopic field in the CA1 area. (d) Representative photographs showing APP immunoreactivity in the cortex. (e) APP-positive cells per 400x microscopic field in the cortex. In (b,d), scale bar represents 100 μm. Arrows indicate APP-immunoreactive cells. In (c,e), , , and , refer to the differences from the vehicle group. Error bars denote S.E.M ).