Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta

Figure 4

Cumulative concentration-response curves for butanolic fraction (BF) in aortic rings with intact endothelium precontracted with (a) phenylephrine (Phe) (0.1 μM) in the presence of Nω-nitro-L-arginine methyl ester (L-NAME) (a nitric oxide synthase inhibitor, 100 μM) or 1H-[1,2,4]oxadiazolo [4,3-alpha]quinoxalin-1-one (ODQ) (a guanylylcyclase inhibitor, 100 μM) and (b) precontracted with KCl (120 mM) in the presence or absence of L-NAME (100 μM). The results show the mean ± SEM of 6–8 experiments. ^∗𝑃<0.05 when to control (Phe or KCl).

(a)

(b)