Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 934258, 7 pages
http://dx.doi.org/10.1155/2012/934258
Research Article

Hypoglycemic Activity of Aqueous Extracts from Catharanthus roseus

División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Avenida San Rafael Atlixco 186, Colonia Vicentina, 09340 México, DF, Mexico

Received 31 May 2012; Revised 7 August 2012; Accepted 10 August 2012

Academic Editor: Pierre Kamtchouing

Copyright © 2012 Elisa Vega-Ávila et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. I. G. Holt, “Diagnosis, epidemiology and pathogenesis of diabetes mellitus: an update for psychiatrists,” British Journal of Psychiatry, vol. 184, pp. S55–S63, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. D. M. Nathan, “Long-term complications of diabetes mellitus,” New England Journal of Medicine, vol. 328, no. 23, pp. 1676–1685, 1993. View at Publisher · View at Google Scholar · View at Scopus
  3. R. Collins, J. Armitage, S. Parish, P. Sleigh, and R. Peto, “MRC/BHF heart protection study of cholesterol-lowering with simvastatin in 5965 people with diabetes: a randomized placebo-controlled trial,” The Lancet, vol. 361, pp. 2005–2016, 2003. View at Publisher · View at Google Scholar
  4. C. A. Aguilar-Salinas, O. V. Monroy, F. J. Gómez-Pérez et al., “Characteristics of patients with type 2 diabetes in México: results from a large population-based nationwide survey,” Diabetes Care, vol. 26, no. 7, pp. 2021–2026, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. H. King, R. E. Aubert, and W. H. Herman, “Global burden of diabetes, 1995–2025: prevalence, numerical estimates, and projections,” Diabetes Care, vol. 21, no. 9, pp. 1414–1431, 1998. View at Google Scholar · View at Scopus
  6. A. Akhtar, M. Rashid, M. I. I. Wahed et al., “Comparison of long-term antihyperglycemic and hypolipidemic effects between Coccinia cordifolia (Linn.) and Catharanthus roseus (Linn.) in alloxan-induced diabetic rats,” Research Journal of Medical Sciences, vol. 2, pp. 29–34, 2007. View at Google Scholar
  7. S. Nammi, M. K. Boini, S. D. Lodagala, and R. B. Behara, “The juice of fresh leaves of Catharanthus roseus Linn. reduces blood glucose in normal and alloxan diabetic rabbits,” BMC Complementary and Alternative Medicine, vol. 3, article 4, 2003. View at Google Scholar · View at Scopus
  8. D. Mahabir and M. C. Gulliford, “Use of medicinal plants for diabetes in Trinidad and Tobago,” Revista Panamericana de Salud Publica/Pan American Journal of Public Health, vol. 1, no. 3, pp. 174–179, 1997. View at Google Scholar · View at Scopus
  9. B. S. Nayak and L. M. Pinto Pereira, “Catharanthus roseus flower extract has wound-healing activity in Sprague Dawley rats,” BMC Complementary and Alternative Medicine, vol. 6, article 41, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Iwase, H. Aoyagi, M. Ohme-Takagi, and H. Tanaka, “Development of a novel system for producing ajmalicine and serpentine using direct culture of leaves in Catharanthus roseus intact plant,” Journal of Bioscience and Bioengineering, vol. 99, no. 3, pp. 208–215, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. S. N. Singh, P. Vats, S. Suri et al., “Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats,” Journal of Ethnopharmacology, vol. 76, no. 3, pp. 269–277, 2001. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Andrade-Cetto and M. Heinrich, “Mexican plants with hypoglycaemic effect used in the treatment of diabetes,” Journal of Ethnopharmacology, vol. 99, no. 3, pp. 325–348, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Mendonça-Netto, R. W. B. Varela, M. F. Fechine, M. N. G. Queiroga, F. N. Souto-Maior, and R. N. Almeida, “Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents,” Brazilian Journal of Pharmacognosy, vol. 18, no. 2, pp. 165–169, 2008. View at Google Scholar · View at Scopus
  14. B. Maldoni, “Alkaloids: isolation and purification,” Journal of Chemical Education, vol. 68, no. 8, pp. 700–703, 1991. View at Google Scholar · View at Scopus
  15. X. A. Domínguez, Métodos De Investigación Fitoquímica, Limusa, México. Mexico, 1st edition, 1973.
  16. S. K. Prasad, A. Kulshreshtha, and T. N. Qureshi, “Antidiabetic activity of some herbal plants in streptozotocin induced diabetic albino rats,” Pakistan Journal of Nutrition, vol. 8, no. 5, pp. 551–557, 2009. View at Google Scholar · View at Scopus
  17. S. C. Ohadoma and H. U. Michael, “Effects of co-administration of methanol leaf extract of Catharanthus roseus on the hypoglycemic activity of metformin and glibenclamide in rats,” Asian Pacific Journal of Tropical Medicine, vol. 4, no. 6, pp. 475–477, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. C. A. Jaleel, B. Sankar, R. Sridharan, and R. Panneerselvam, “Soil salinity alters growth, chlorophyll content, and secondary metabolite accumulation in Catharanthus roseus,” Turkish Journal of Biology, vol. 32, no. 2, pp. 79–83, 2008. View at Google Scholar · View at Scopus
  19. M. Bnouham, A. Ziyyat, H. Mekhfi, A. Tahri, and A. Legssyer, “Medicinal plants with potential antidiabetic activity—a review of ten years of herbal medicine research (1990–2000),” International Journal of Diabetes and Metabolism, vol. 14, no. 1, pp. 1–25, 2006. View at Google Scholar · View at Scopus
  20. F. Ferreres, D. M. Pereira, P. Valentão, P. B. Andrade, R. M. Seabra, and M. Sottomayor, “New phenolic compounds and antioxidant potential of Catharanthus roseus,” Journal of Agricultural and Food Chemistry, vol. 56, no. 21, pp. 9967–9974, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. F. Ferreres, R. Figueiredo, S. Bettencourt et al., “Identification of phenolic compounds in isolated vacuoles of the medicinal plant Catharanthus roseus and their interaction with vacuolar class III peroxidase: an H2O2 affair?” Journal of Experimental Botany, vol. 62, no. 8, pp. 2841–2854, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. A. K. Shetty, R. Rashmi, M. G. R. Rajan, K. Sambaich, and P. V. Salimat, “Antidiabetic influence of querecetin in streptozotocin-induced diabetic rats,” Nutrition Research, vol. 24, pp. 373–381, 2004. View at Publisher · View at Google Scholar
  23. C. C. Rerup, “Drugs producing diabetes through damage of the insulin secreting cells,” Pharmacological Reviews, vol. 22, no. 4, pp. 485–518, 1970. View at Google Scholar · View at Scopus
  24. F. M. Ashcroft and F. M. Gribble, “ATP-sensitive K+ channels and insulin secretion: their role in health and disease,” Diabetologia, vol. 42, no. 8, pp. 903–919, 1999. View at Publisher · View at Google Scholar · View at Scopus