Hypoglycemic Activity of Aqueous Extracts from Catharanthus roseus

Table 1

Percentage blood glucose reduction produced by extracts from Catharanthus roseus after intraperitoneal administration in healthy mice.

Treatment (𝑛=6)	Dose	In fasting blood glucose (mg/dL)		Percentage blood glucose reduction
			2 h	4 h	6 h
Control	mL/Kg
Saline solution	6.6	55.8±11.9	3.04±0.37	−𝟖.𝟗±𝟏.𝟎𝟓𝟏	1.43±0.150
Corn oil	6.6	53.6±10.2	15.61±0.89	14.92±0.74	22.01±0.29
Flower	mg/Kg
Hexane	250	43.2±11.0	13.65±1.62	27.77±1.28^∗	15.50±0.063
Dichloromethane	250	58.8±15.3	−𝟏.𝟕𝟎±𝟎.𝟐𝟕𝟕	22.61±4.26	28.06±4.06^∗
Methanol	250	48.4±17.2	19.00±3.28	22.52±3.40	26.03±4.00
Aqueous	250	51.3±9.30	49.70±3.98^∗	36.64±3.91^∗	33.13±2.32^∗
Root	mg/Kg
Hexane	250	50.6±5.10	−𝟒𝟎.𝟗𝟎±𝟑.𝟑𝟔	0.592±3.36	0.592±0.075
Dichlorometane	250	50,0±4.50	−𝟒𝟐.𝟔±𝟑.𝟖𝟎	−𝟒𝟓.𝟒±𝟐.𝟖𝟓	−𝟏𝟕.𝟔±𝟐.𝟎𝟔
Methanol	250	50.8±8.26	−𝟏𝟖.𝟏𝟏±𝟐.𝟐𝟏	−𝟏𝟖.𝟏𝟏±𝟏.𝟑𝟖	−𝟏𝟕.𝟑𝟐±𝟏.𝟔𝟖
Aqueous	250	54.8±4.91	−𝟖.𝟕𝟓±𝟎.𝟒𝟏	27.33±2.66^∗	28.10±1.035^∗
Stem	mg/Kg
Hexane	250	50.7±10.2	−𝟑.𝟗𝟒±𝟏.𝟐𝟏	11.84±0.77	19.13±0.75
Dichlorometane	250	52,2±9.90	−𝟏𝟗.𝟓±𝟏.𝟐𝟏	0.76±0.059	10.53±0.58
Methanol	250	50.3±7.55	−𝟐𝟕.𝟓𝟓±𝟏.𝟕𝟏	−𝟓.𝟑𝟔±𝟎.𝟏𝟏	7.5±0.539
Aqueous	250	54.7±8.40	−𝟖.𝟗𝟓±𝟎.𝟔𝟐𝟏	21.93±1.42	30.16±3.19^∗
Leaf	mg/Kg
Hexane	250	53.0±15.4	−𝟑𝟒.𝟑𝟑±𝟒.𝟒𝟒	−𝟔.𝟗𝟖±𝟎.𝟑𝟐	9.4±0.53
Dichlorometane	250	52.2±18.6	−𝟐𝟔.𝟒𝟑±𝟑.𝟖𝟐	−𝟏𝟏.𝟑𝟎±𝟏.𝟗𝟖	3.25±0.24
Methanol	250	45.2±10	−𝟑𝟗.𝟑𝟖±𝟓.𝟔𝟏	−𝟎.𝟐𝟐±𝟎.𝟎𝟗𝟎	−𝟐.𝟒𝟑±𝟎.𝟐𝟔𝟔
Aqueous	250	48.6±7.10	15.02±2.56	26.74±2.05^∗	50.61±8.78^∗

Values are mean percentage blood glucose reduction (±S.E.M.). *Significant differences from glycemia in fasting (𝑃<0.05). 𝑛=6.